(BAFLA- Barzilai Fatty Liver and Iron Metabolism Study)
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- grade of fatty liver disease
研究概览
简要总结
The investigators hypothesize that low iron storages protects from and down-grades non-alcoholic fatty liver disease.
The aim of the study is to show the association between the severity of Non-alcoholic fatty liver disease to low iron status.
详细描述
Patients that will pass a CT scan that includes the abdomen will be asked to participate at our study. These patients will be divided into two groups - with and w/o fatty liver. The severity of fatty liver will be determined using the CT scan (as well as other parameters, such as the size of subcutaneous fat layer). Within 72 hours from the scan, a venous blood test will be taken from the enrolled patients (together with a BMI calculation and a blood pressure measurements). In the blood test we will examine liver functions, iron status etc.
This is a preliminary study that will aid in planning future strategies to treat or even prevent fatty liver (one of the epidemics of our century).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- •pregnancy
- •unable to sign an informed consent (legally)
- •known solid/hematological malignancy
- •hemoglobinopathy or myelodysplastic disease (not including G6PD deficiency)
- •active or carrier of viral hepatitis
- •treated a drug the cause fatty liver (eg. amiodarone, tetracyclin, HAART, steroid treatment > 3 months)
- •consumption of > 120g ethanol per week
- •primary liver disease (eg. glycogen storage disease)
- •acute intoxication
- •surgery in previous 7 days
结局指标
主要结局
grade of fatty liver disease
时间窗: 1 year
次要结局
未报告次要终点
研究者
Ornit Cohen
r&d unit
Barzilai Medical Center