Association of Processing Speed Dysfunction and Brain Functional Abnormality in Childhood Epilepsy With Centrotemporal Spikes
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Epilepsy, Rolandic
- Sponsor
- Second Affiliated Hospital, School of Medicine, Zhejiang University
- Enrollment
- 68
- Locations
- 1
- Primary Endpoint
- Processing speed index
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Epilepsy with centrotemporal spikes (ECTS) is the most common epilepsy syndrome in children. Language impairment has been widely investigated in patients with ECTS, but little is known about the cognitive dysfunction of processing speed and its neuroimaging mechanism.
Detailed Description
OBJECTIVE To investigate the processing speed dysfunction in patients with ECTS, and the associated brain functional abnormality using functional magnetic resonance imaging (fMRI) and 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET). DESIGN, SETTING, AND PARTICIPANTS This study prospectively enrolled ECTS patients (n = 28) from June 2019 and June 2021. Twenty age- and gender- matched healthy children and another twenty children with extracranial tumors were enrolled as controls. Patients with ECTS and healthy controls underwent neuropsychological testing and fMRI examination. In addition, ECTS patients and children with extracranial tumors underwent 18F-FDG PET examination.
Investigators
Eligibility Criteria
Inclusion Criteria
- •(a) age between 6 and 18 years; (b) 18F-FDG PET examination more than 48 h since the last seizure, (c) no structural abnormalities associated with epilepsy detected on routine MRI
Exclusion Criteria
- •(a) any history of other neurological or psychiatric disorders; (b) pre-scan plasma glucose level \> 120 mg/dl before 18F-FDG PET/CT examination;(c) any contraindications for MRI examination ; (d) head movement (translation \> 3 mm or rotation \> 3 degree ) during MRI examination
Outcomes
Primary Outcomes
Processing speed index
Time Frame: Through study completion, about 2 years
Processing speed index was measured according to Wechsler Intelligence Scale for Children
Standardized uptake value ratio
Time Frame: Through study completion, about 2 years
Standardized uptake value ratio was measured from 18F-FDG PET for brain glucose metabolism
Functional connectivity
Time Frame: Through study completion, about 2 years
Functional connectivity was measured from fMRI for brain regional interactions