Clinical and Neurophysiological Assessment of Pelvic Floor Dysfunction in Patients With Multiple Sclerosis
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 120
- 主要终点
- Clinical assessment of bowel, bladder, and sexual dysfunction in patients with MS though applying specific related scales
研究概览
简要总结
Primary objective
- Clinical assessment of bowel, bladder, and sexual dysfunction in patients with MS
- Impact of sphincter disorders on quality of life in patients with MS by using correlation between Extended Disability Status Scale (EDSS)and The Incontinence Quality of Life Questionnaire (IQOL)
Secondary objectives
-Studying the effect of low frequency rTMS on bladder symptoms in patients with MS.
详细描述
2.4.1- Type of the study: This study will be a cross-section observational study. 2.4. 2- Study Setting: neuology unit assuit university hospital 2.4. 3- Study subjects: From the neurologic outpatient clinic in Assiut University and patients referred from our staff members in Neuropsychiatry department.
- Inclusion criteria:
Adult patient with definite Multiple sclerosis according to Mcdonald's Criteria (revised criteria 2017), Age > 18 years both sexes patient with subjective complaint of any of pelvic floor dysfunction (bladder, sexual or bowel) 2. Exclusion criteria:
Patients with other systemic or neurological disorder affecting sphincter (Diabetes Mellitus, Renal diseases, Urinary tract infection, epilepsy, peripheral neuropathy, irritable bowel syndrome.....) Patients taking drugs affecting sphincter as psychotropic drugs
2.4.4 -Study tools (in detail, e.g., lab methods, instruments, steps, chemicals, ...): Step I Patients will be assessed through full neurological history and examination with
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •1.Adult patient with definite Multiple sclerosis 2-Age > 18 years 3-both sexes 4-patient with complaint of any of pelvic floor dysfunction (bladder, sexual or bowel)
排除标准
- •Patients with other systemic or neurological disorder affecting sphincter.
- •Patients taking drugs affecting sphincter.
结局指标
主要结局
Clinical assessment of bowel, bladder, and sexual dysfunction in patients with MS though applying specific related scales
时间窗: Baseline
Clinical assessment of bowel, bladder, and sexual dysfunction in patients with MS though applying specific related scales
次要结局
- Motor evoked potential using TMS with parameters gained using single pulse paradigm(Baseline)
研究者
Yosra Abdallah Hassan
Principal investigator
Assiut University