The Effect of Food Stimuli on the Calorie Restriction Response in Healthy Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 12
- 主要终点
- Endocrine and metabolic outcomes
研究概览
简要总结
Calorie restriction extends life span and prevents aging-related diseases in several species. Odorants from live yeast restrain the beneficial effects of calorie restriction in Drosophila Melanogaster. The investigators hypothesize that visual and odorous food stimuli impact the neuroendocrine and metabolic response to starvation in healthy humans.
In this randomized cross-over intervention study 12 healthy, young men will fast twice for 60-hours in the presence or absence of food-related visual and odorous stimuli. At baseline and on the last morning of each intervention an oral glucose tolerance test (OGTT) will be performed. During the OGTT blood is sampled and hypothalamic neuronal activity is measured by functional MRI.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Caucasian male volunteers
- •Age > 18 years and < 70 years
- •Body mass index (BMI) > 20 kg/m2 and < 25 kg/m2
- •Fasting serum glucose (FSG) < 6.1 mmol/L
排除标准
- •Any significant chronic of hereditary disease (including renal, hepatic or endocrine disease)
- •Any significant abnormal laboratory results found during the medical screening procedure
- •Any use of medication (except for NSAID)
- •Anosmia or any other (acquired) loss of olfaction (ea. rhinitis)
- •Recent weight changes or attempts to loose weight (> 3 kg weight gain or loss, within the last 3 months)
- •Difficulties to insert an intravenous catheter
- •MRI contraindications
- •Recent blood donation (within the last 3 months)
- •Recent participation in other research projects (within the last 3 months), participation in 2 or more projects in one year
结局指标
主要结局
Endocrine and metabolic outcomes
时间窗: 4 weeks
The effects of odors and / or visual stimuli of food in subjects after 60h of starvation on: endocrine parameters, metabolic parameters, anthropometric parameters
次要结局
- functional Magnetic Resonance Imaging(4 weeks)
研究者
Hanno Pijl
Prof. dr. H. Pijl
Leiden University Medical Center