NCT00880386撤回不适用
A Pilot Project to Determine the Effect of Losartan (Cozaar) on Radiation-Induced Pulmonary Fibrosis in Patients With Non-Small Cell Lung Cancer
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 主要终点
- Change in carbon monoxide diffusing capacity (DLCO) at 6 months
研究概览
简要总结
RATIONALE: Losartan potassium may be effective in treating pulmonary fibrosis caused by radiation therapy in patients with non-small cell lung cancer.
PURPOSE: This clinical trial is studying losartan to see how well it works in treating pulmonary fibrosis caused by radiation therapy in patients with stage I, stage II, or stage III non-small cell lung cancer.
详细描述
OBJECTIVES:
Primary
- To evaluate the effects of losartan potassium on the disease progression in patients with stage I-III non-small cell lung cancer and radiation-induced pulmonary fibrosis.
- To determine the feasibility of losartan potassium as a possible treatment for radiation-induced pulmonary fibrosis.
Secondary
- The evaluate the effects of losartan potassium on the degree of dyspnea, and lung function (FEV_1 and FVC) in these patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Losartan Group
Experimental
50 mg Losartan tablet taken daily for 24 weeks
干预措施: Losartan (Drug)
结局指标
主要结局
Change in carbon monoxide diffusing capacity (DLCO) at 6 months
时间窗: 6 months
次要结局
- Feasibility of losartan potassium as treatment for radiation-induced pulmonary fibrosis(6 months)
- Pulmonary function measurements of FEV1 and FVC and dyspnea score at 6 months(6 months)
研究者
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