ovel Adverse Effect of Tranexamic Acid in Adolescent Idiopathic Scoliosis Surgery
- Conditions
- Scoliosis
- Registration Number
- PACTR201805003406118
- Lead Sponsor
- Ain Shams University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 75
This randomized controlled clinical trial will be conducted on 75 patients with American Society of Anesthesiologists (ASA) physical status I and II, of either sex, 12-18 years of age, who will be scheduled for elective single stage posterior spine fusion surgery for idiopathic scoliosis under general anesthesia.
Patients known to have renal or hepatic disorder, bleeding diathesis, thromboembolic event 1 year prior to surgery, preoperative anemia (hemoglobin < 11 g/dL in females; hemoglobin < 12 g/dL in males), preoperative platelet count < 150,000/mm3, International Normalized Ratio (INR) > 1.4 and history of uncontrolled hypertension will be dismissed from the study.
Additionally, patients with neuromuscular disease, congenital or syndromic scoliosis or surgery performed via either combined anterior and posterior spinal fusions or the anterior procedure are excluded. Severe pulmonary disease, i.e., FEV1 < 50% normal will be also excluded from the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Total dose given of intraoperative fentanyl
- Secondary Outcome Measures
Name Time Method Intraoperative blood loss, time of surgery and perioperative complications