Constitution of a Prospective Cohort of Patients With Acute Suppurative Hidrosadenitis Followed in the Great West: the COVER Cohort (Verneuil Cohort)

Recruiting

• Conditions: Acute Hidrosadenitis
• Interventions: Other: no interventional study

• Registration Number: NCT04352036
• Lead Sponsor: Nantes University Hospital

Brief Summary

Our primary objective with this cohort will be to define the different phenotypes of acute hidrosadenitis, the characterization of which is essential to define suitable therapeutic approaches. Indeed, our recent data allow us to note that there would be different phenotypes of acute hidrosadenitis and therefore different pathologies inducing different follow-ups and care.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-04-10
• Study First Submitted QC: 2020-04-15
• Study First Posted: 2020-04-17
• Status Verified: 2022-01
• Study Start: 2022-01-04
• Last Update Submitted: 2022-01-20
• Last Update Posted: 2022-01-21
• Primary Completion: 2030-02-20
• Study Completion: 2030-02-20

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 465

Inclusion Criteria

• Patient diagnosed with acute hidrosadenitis by a dermatologist
• Patient agreeing to be part of the study

Exclusion Criteria

• No affiliation to a social security scheme
• Major under guardianship
• Protected persons

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
patient	no interventional study	-

Primary Outcome Measures

Name	Time	Method
Description of the natural history and identification of the different clinical forms of acute hidrosadenitis	through study completion, an average of 3 years	history of the disease, classification of Hurley, Canoui-Poitrine and van der Zee and Jemec
Prevalence of severe forms (grade II, III)	through study completion, an average of 3 years	Number of patients with severe disease (grades II and III)
Involvement of innate immunity in the development of this chronic inflammation with skin biopsies for bacteriological samples	through study completion, an average of 3 years	skin biopsies of a closed nodule and axillary and inguinal bacteriological samples
Determine the impact of vitamin D deficiency on inflammatory bowel disease	through study completion, an average of 3 years	skin biopsies of a closed nodule and axillary and inguinal bacteriological samples
Definition of different phenotypes of acute hidrosadenitis	through study completion, an average of 3 years	patient history, Canoui-Poitrine and van der Zee and Jemec classification, blood and urine tests, imaging
Identify the environmental factors associated with the chronicity of the disease	through study completion, an average of 3 years	lifestyle questionnaire assessing the impact on quality of life
Determine the impact of IGF1 deficiency on inflammatory bowel disease	through study completion, an average of 3 years	skin biopsies of a closed nodule and axillary and inguinal bacteriological samples

Trial Locations

Locations (13)

Chr D'Orléans; 🇫🇷 Orléans, France

CH; 🇫🇷 Le Mans, France

CH bretagne sud; 🇫🇷 Lorient, France

Chru Brest; 🇫🇷 Brest, France

CHD Vendée; 🇫🇷 La Roche Sur Yon, France

CHRU Tours; 🇫🇷 Tours, France

CHU Angers; 🇫🇷 Angers, France

CH La Rochelle; 🇫🇷 La Rochelle, France

CHU de Nantes - Dermatologie; 🇫🇷 Nantes, France

CHU Pontchaillou; 🇫🇷 Rennes, France

Ch Saint-Brieuc; 🇫🇷 Saint-Brieuc, France

CHU Milétrie; 🇫🇷 Poitiers, France

Ch de Cornouaille; 🇫🇷 Quimper, France