Clinical Observational Research on Changes of Peripheral Blood Mononuclear Cell（PBMC） Immunity and Expression Profile in Peripheral Blood of Different Course of of Vogt-Hoyanagi-Harada（VKH） Patients.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- T/B /NK(natural killer )/monocyte...etc, cell numbers of blood samples in VKH patients
研究概览
简要总结
The investigators will collect blood samples of different courses of VKH patients for investigating immune profile, observe major immune cells number ,functional and membrane molecular changes in the course of treatment, to investigate pathogenesis of VKH. Meanwhile, the investigators will collect clinical data of VKH patients to observe choroid and retina change in different courses.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Acute VKH patients, meet a criterion of VKH, no recurrence.
- •Age range from 18 to 50 years old.
排除标准
- •Patients with Severe Cardiovascular and Cerebrovascular Diseases
- •Patients allergic to steroid or contrast agents;
- •A history of ocular trauma or intraocular surgery within 3 months; Vaccinated; History of infectious diseases
- •having a history of heredity, immune system correlation, neuroendocrine and digestive system diseases
- •Patients who take health care products for a long time and have heavy alcohol and tobacco addiction.
研究组 & 干预措施
VKH patients
acute VKH patients
干预措施: Steroids (Drug)
结局指标
主要结局
T/B /NK(natural killer )/monocyte...etc, cell numbers of blood samples in VKH patients
时间窗: one year
use flow cytometry to count T/B /NK/monocyte...etc, cell numbers
T/B /NK/monocyte...etc cell functional change in VKH patients
时间窗: one year
use ELISA(enzyme linked immunosorbent assay) to measure inflammatory cytokines level in peripheral blood
T/B /NK/monocyte...etc cell subtype proportion in blood samples in VKH patients
时间窗: one year
use flow cytometry to measure T/B /NK/monocyte...etc cell subtype proportion
次要结局
- measure the Injury degree of choroid and retinal vessels(one year)
- choroid and retinal thickness change in different course of VKH patients(one year)
- Use OCTA(optical coherence tomography angiography) to measure macular and optic disc vascular index(one year)
- Use Maia perimeter to measure macular integrality(one year)