Impact of Air Pollution on the Autonomic Nervous System Activity and the Presence of Sleep Apnea in Older Subjects: Longitudinal Multicentric Study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 60
- Locations
- 2
- Primary Endpoint
- Frequency analysis of heart rate variability
Study Overview
Brief Summary
Impact of air pollution on the autonomic nervous system activity and presence of sleep apnea in older subjects.
Detailed Description
The relation between the air pollution and morbidity, cardiovascular mortality was increasing interest. Analyses show an increase of respiratory difficulty, but also cardiac deaths in the daytime when the atmospheric pollution was increased. It was demonstrated that health effects of ambient air pollution in subjects presenting cardiac or lung difficulty were important. Mechanisms show a possible relation to autonomic nervous system (ANS) deactivation and mortality. Particularly, the ageing and ANS reach would be more predictive of cardiovascular events. Thus, we suggest estimating in 60 healthy volunteers from 60 to 80 years old, the impact of the air pollution on the autonomic nervous system activity and sleep apnea consequences.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 60 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •reside in Lyon and Saint-Etienne cities
- •security social affiliated or beneficiary
- •information note signed
Exclusion Criteria
- •heart rate disorders
- •pacemaker
- •tabacco addiction or second-hand smoke
- •morbid obesity (BMI > 30)
- •insulin-dependent diabetes
- •chronic disease on treatment
- •antiarrythmic treatments
Outcomes
Primary Outcomes
Frequency analysis of heart rate variability
Time Frame: inclusion, 1 test night and 2 experimental nights
Secondary Outcomes
- Analysis of sleep, diurnal somnolence, sleep latency and PRS impact on the life quality.(1 test night and 2 experimental nights)
- Hour index quantification of night respiratory events.(1 test night and 2 experimental nights)
- Hour index quantification of autonomic awakening during the sleep.(1 test night and 2 experimental nights)