Role of the Posterior Parietal Cortex in the Processing of Sensory Information

Not Applicable

• Conditions: Healthy Subject
• Interventions: Device: Transcranial Magnetic Stimulation (TMS); Device: Electrical Muscle Activity (EMG)

• Registration Number: NCT03386188
• Lead Sponsor: University Hospital, Lille

Brief Summary

Although the primary motor cortex is considered has the common final pathway of motor commands, it is influenced by several structures as, for example, the premotor cortex and the posterior parietal cortex which are involved in motor planning and programming and which integrates movement-induced sensory impute (parieto-frontal circuits). Several studies have shown that there are some direct functional connections between the premotor cortex and the posterior parietal cortex and from these two regions to the primary motor cortex. The posterior parietal cortex can then be considered as a sensorimotor interface whose function in planification and motor control of upper limb is well demonstrated. The hypothesis is that the posterior parietal cortex could participate to the modulation of motor cortex excitability by proprioceptive sensory inputs namely long latency afferent inhibition and afferent induced facilitation.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-01
• Study First Submitted: 2017-12-14
• Study First Submitted QC: 2017-12-20
• Study First Posted: 2017-12-29
• Status Verified: 2020-08
• Last Update Submitted: 2020-08-24
• Last Update Posted: 2020-08-25
• Primary Completion: 2021-01-18
• Study Completion: 2021-07-18

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Right handed
• No neurological troubles
• Informed consent signed
• Affiliated to a social security

Exclusion Criteria

• Psychiatric antecedent
• Neurological disease
• Contra-indication to TMS
• Under psychiatric treatment
• Pregnancy
• Contra-indication to MRI

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Healthy arm	Electrical Muscle Activity (EMG)	posterior parietal cortex (PPC) transitory inactivation
Healthy arm	Transcranial Magnetic Stimulation (TMS)	posterior parietal cortex (PPC) transitory inactivation

Primary Outcome Measures

Name	Time	Method
Afferent induced facilitation	Baseline	Motor cortex facilitation following median nerve stimulation at interstimulus intervals of 70ms

Secondary Outcome Measures

Name	Time	Method
Interaction between long latency afferent inhibition and long latency intracortical inhibition (LICI)	Baseline	Effect of median nerve stimulation on LICI at 100ms interval

Trial Locations

Locations (1)

Hôpital Roger Salengro, CHRU de Lille; 🇫🇷 Lille, France