Functional Renal Hemodynamics in Patients with and without Renal Artery Stenosis 2

Completed

• Conditions: atherosclerotic renal artery stenosis; renovasculair disease; secundaire hypertensie; 10038430; 10057166

• Registration Number: NL-OMON55815
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 28

Inclusion Criteria

Age > 18
Written informed consent
Clinically and hemodynamically stable
Clinical indication for a coronary, renal, or peripheral vascular angiography
with or without percutaneous intervention.

Exclusion Criteria

Recent ST-segment elevation myocardial infarction (<6 weeks prior to enrolment)
Known cardiac arrhythmias
Known heart failure (NYHA class > II)
Increased risk for contrast nephropathy defined as presence of renal impairment
(eGFR <30ml/min) according to the Guideline Safe Use of Contrast Media of the
Radiology Society of the Netherlands (November 2017)
Women of child bearing age not on active birth control
Inability to sign an informed consent, due to any mental condition that renders
the
subject unable to understand the nature, scope, and possible consequences of
the trial or due to mental retardation or language barrier

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Dynamic range of renal blood flow, represented by the relative baseline flow,<br /><br>the ratio between the difference of baseline and minimal flow velocity and<br /><br>baseline flow velocity.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Renal flow reserve, relative minimal flow, renal fractional flow reserve,<br /><br>baseline and hyperemic renal stenosis resistance, baseline and hyperemic<br /><br>microvascular resistance, phase difference between pressure and flow in<br /><br>sympathetic band for autoregulation.<br /><br><br /><br>In patients where offline renal perfusion analysis is possible: renal perfusion<br /><br>as area under the curve of contrast density over time and the renal flow<br /><br>reserve computed by perfusion angiography.<br /><br><br /><br>Correlation of main study parameters with relevant clinical, biochemical and<br /><br>imaging parameters.</p><br>