Brain natriuretic peptide as an early predictor of toxic myocarditis after burn: A prospective observational study

Not Applicable

Recruiting

• Conditions: Circulatory System; Injury, Occupational Diseases, Poisoning; Cardiology

• Registration Number: PACTR202308864962981
• Lead Sponsor: Faculty of medicine Ain Shams University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-08-07
• Last Update Posted: 4 March 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1-Age: eligible = 21 - = 60 yrs.
2-Sex: eligible both sexes.
3-Patients with American Society of Anesthesiologists (ASA) physical status I-II.
4-Patients with Total Burn Surface area (TSBA) = 20% up to = 50%
5-Patients with 2nd degree burn or more.

Exclusion Criteria

1-< 21 or > 60 years old.
2-Declining to give written informed consent.
3-Patients with preexisting cardiac or pulmonary diseases e.g., hypertension, congenital heart disease, ischemic heart disease with impaired cardiac function, valvular heart disease, heart failure, infective endocarditis.
4-Patients with severe hepatic impairment (INR = 1.5, Bilirubin = 2, Albumin = 2).
5-Patients with renal dysfunction (GFR < 50ml/min).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
?The primary outcome will be the sensitivity and specificity of the BNP plasma level as an early predictor of the incidence of toxic myocarditis

Secondary Outcome Measures

Name	Time	Method
the secondary outcomes will be the incidence of other complications such as sepsis and other organ failure as well as ICU stay and total hospital stay.