Diagnostic Performance of a Modified AORTAs Score Integrated With Environmental Exposure Data for Acute Aortic Syndrome Identification : The EnvScore-Aorte Diagnostic Study Protocol
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 580
- 主要终点
- Area Under the Receiver Operating Characteristic (ROC) Curve (AUC) of the AORTAs scores.
研究概览
简要总结
The goal of this retrospective observational study is to evaluate the diagnostic performance of the AORTAs score integrated with environmental exposure data (AORTAs-E) for the identification of Acute Aortic Syndrome (AAS) during initial maangement in the emergency departement.
The main question it aims to answer is:
Can the integration of real-time meteorological and atmospheric pollution data improve the early identification of AAS in patients presenting in the emergency department for chest, abdominal, or back pain?
Researchers will analyze medical records and environmental data for 580 adult patients (290 cases with confirmed AAS and 290 controls) managed at the University Hospital of Besançon between 2014 and 2026. Environmental exposure, including temperature and pollutant concentrations, will be calculated based on each patient's residential address to determine if adding these factors to clinical data increases diagnostic accuracy.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •(Cases - AAS+) :
- •Adults (>18 years)
- •Diagnosis of AAS (aortic dissection, intramural hematoma, or penetrating atherosclerotic ulcer) identified according to medicalization programs for information systems
- •Diagnosis confirmed by imaging (CTA, TTE, or TOE)
- •Inclusion Criteria (Controls - AAS-):
- •Adults (>18 years)
- •Presenting in the emergency department for chest, back, or abdominal pain.-
- •Confirmed differential diagnosis by CTA, ruling out AAS
排除标准
- •Post-traumatic or iatrogenic AAS.
- •Subacute (8-30 days) or chronic symptoms (>30 days).
- •Patients under legal protection or unable to provide consent/non-opposition.
研究组 & 干预措施
AAS- Group
Controls
AAS+ Group
Cases
结局指标
主要结局
Area Under the Receiver Operating Characteristic (ROC) Curve (AUC) of the AORTAs scores.
时间窗: From January 2014 to January 2026
Comparison of the diagnostic performance between the four scores: original AORTAs, AORTAs-E (Environmental), AORTAs-R (emergency medical dispatch), and AORTAs-R+E (Combined).
次要结局
未报告次要终点