A pilot study to investigate the feasibility of a combined exercise and nutrition prehabilitation program for patients with endometrial cancer scheduled for surgery

King Edward Memorial Hospital0 sites20 target enrollmentFebruary 22, 2024

Overview

No summary available.

Registry

who.int

Start Date

February 22, 2024

End Date

TBD

Last Updated

2 years ago

Study Type

Interventional

Sex

Female

Sponsor

•1\.Low grade (grade 1\) endometrioid endometrial adenocarcinoma
•2\.Presumed early stage (Federation of Gynecology and Obstetrics stage 1A) on physical
•examination and imaging (CT chest, abdomen, and pelvis)
•3\.At least one of the following cardiovascular risk factors: overweight (BMI greater than or
•equal to 25kg/m2\) or obese (BMI greater than or equal to 30kg/m2\), hypertension, type
•2 diabetes, hypercholesterolaemia, self\-reported physical inactivity (less than 150
•minutes per week of moderate activity such as walking, gardening, swimming, cycling,
•gym), smoking
•4\.Planned to undergo definitive surgery (total hysterectomy, bilateral salpingo\-
•oophorectomy \+/\- sentinel lymph node biopsies)

•1\.Medical contraindication to exercise or the use of a very low\-calorie diet, including
•physical impairments, lactation, presence of porphyria, severe hepatic disease,
•advanced renal disease, unstable cardiac disease (recent myocardial infarction or
•unstable angina), type 1 diabetes mellitus, overt psychosis, alcoholism, or drug abuse
•2\.Patients on lithium, corticosteroids, anticonvulsants (although not a contraindication to
•Optifast, requires extra monitoring beyond the scope of this study)
•3\.Evidence of extra\-uterine disease clinically or on medical imaging
•4\.Histological cell types including serous, clear cell, carcinosarcoma, sarcoma, de\-
•differentiated
•5\.Moderately differentiated or poorly differentiated (grades 2 and 3\) endometrioid