A treatment algorithm reduces perioperative blood loss in children with congenital stenotic heart disease
- Conditions
- D68.00
- Registration Number
- DRKS00014663
- Lead Sponsor
- Herz- und Diabeteszentrum Nordrhein-Westfalen Universitätsklinik der Ruhr-Universität Bochum Institut für Laboratoriums- und Transfusionsmedizin
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 627
Patients with stenotic congenital heart defects (CHD) undergoing cardiac surgery with cardiopulmonary bypass at the Center for Congenital Heart Defects of the Heart and Diabetes Center NRW in the period from August 2008 to May 2017.
The following CHD were included: valve and vascular stenosis of the aorta and pul-monary artery, coarctation of the aorta, Tetralogy of Fallot, hypertrophic obstructive cardiomyopathy, atrial septal defect, ventricular septal defect and atrioventricular sep-tal defect.
Preoperative antiplatelet therapy (<10 days before surgery), thrombocytopenia (<100*103 *µl-1), coagulation disorder, drugs inducing AVWS, untreated hypothyroidism and administration of von Willebrand factor concentrates or desmopressin (only in the historical cohort)
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Perioperative drainage volume in %<br>The primary endpoint was perioperative blood loss, which was determined by measuring the chest tube drainage from admission to the paediatric intensive care unit until removal of the chest tube or until the moment of clear and serous drainage.
- Secondary Outcome Measures
Name Time Method used blood products