Effect of Moderate Alcohol Consumption on PPAR-γ Activity and Risk Markers of Metabolic Disease: Influence of Genetic Variation in Alcohol Oxidation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 36
- 主要终点
- PPAR-gamma activated gene expression
研究概览
简要总结
Moderate alcohol consumption is associated with a decreased risk of cardiovascular disease and type 2 diabetes. The association of alcohol consumption with cardiovascular disease is mediated by a functional polymorphism of alcohol dehydrogenase 1c, but the effect of this polymorphism on alcohol metabolism is only investigated in vitro.
The risk reduction of moderate alcohol consumption for cardiovascular disease is explained largely by an increase of HDL cholesterol, but an increase of adiponectin concentrations after moderate alcohol consumption may also be involved. It seems likely that adiponectin is a mediator for the association of moderate alcohol consumption with type 2 diabetes. The mechanism by which moderate alcohol consumption increases adiponectin concentrations is unknown, but ppar-gamma activation may be involved.
effects of this polymorphism on mediators of this relation are not known. This study therefore investigates the effect of moderate alcohol consumption and the influence of alcohol dehydrogenase 1c polymorphism on ppar-gamma activated gene expression and risk factors of cardiovascular disease and type 2 diabetes.
详细描述
Objectives :
To investigate the effect of moderate alcohol consumption and influence of genetic variation of ethanol oxidation on:
- PPAR-γ activated gene expression
- Markers of coronary heart disease or type 2 diabetes
- Postprandial changes of HPA-axis activity among 36 postmenopausal women with ADH1C genotype associated with slow or fast alcohol metabolism.
Design : Randomized, controlled, not blinded crossover trial with 1 week wash-out preceding each treatment period
Participants
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Healthy women aged 40 to 65 years
- •Absence of menstrual period for at least 2 years
- •Homozygotes for the ADH1C*1 or ADH1C*2 allele of ADH1C I349V polymorphism
- •Alcohol consumption ≥ 5 and ≤ 21 units/week
排除标准
- •Family history of alcoholism
- •History of medical or surgical events that may significantly affect the study outcome, particularly metabolic or endocrine disorders and gastrointestinal disorders
- •Recent blood donation
结局指标
主要结局
PPAR-gamma activated gene expression
次要结局
- Risk factors of cardiovascular disease and type 2 diabetes
- Postprandial changes of HPA-axis activity