JPRN-jRCT2080221796
未知
1 期
A Phase 1 Study of veliparib (ABT-888) in Combination with Carboplatin/Paclitaxel in Japanese Subjects with solid tumors
适应症Solid tumors
概览
- 阶段
- 1 期
- 干预措施
- 未指定
- 疾病 / 适应症
- Solid tumors
- 发起方
- AbbVie GK
- 入组人数
- 12
- 最后更新
- 2年前
概览
简要总结
暂无简介。
研究者
入排标准
入选标准
- •Patients must have histologically or cytologically confirmed malignant solid tumor.
- •\- Patients who are amenable to standard combination chemotherapy of carboplatin and paclitaxel.
- •\- Patients should have received less than or equal to 1 prior chemotherapy regimens for advanced stage disease.
- •\- Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to 2\.
- •\- Patients must have normal organ and marrow function.
排除标准
- •\- Patients who have had chemotherapy or radiotherapy within 3 weeks (6 weeks for nitrosoureas or mitomycin C)
- •prior to entering the study or the adverse events due to agents administered more than 3 weeks earlier have not recovered to less than grade 2\.
- •\- Known history of allergic reactions to carboplatin or cremophor\-paclitaxel.
- •\- Patients who have previously received a poly(ADP\-ribose) polymerase (PARP) inhibitor.
- •\- Uncontrolled intercurrent illness including, but not limited to, ongoing or active systemic infection requiring treatment, symptomatic congestive heart failure, angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
- •\- History of seizure disorder.
- •\- Hepatitis B surface antigen (HBsAg) positive, Hepatitis C virus (HCV) antibody positive or Human
- •immunodeficiency virus (HIV)\-positive patients.
结局指标
主要结局
未指定
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