NCT03118310已完成2 期
Treatment of NAFLD With Two Different Diets
Karolinska University Hospital1 个研究点 分布在 1 个国家目标入组 74 人开始时间: 2017年4月6日最近更新:
适应症
干预措施
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 74
- 试验地点
- 1
- 主要终点
- Liver fat
研究概览
简要总结
The impact of popular diets on liver-related health is unclear. In this randomized, controlled trial, patients with NAFLD will be randomized to one of two popular diets or a placebo diet.
详细描述
Subjects will include patients with MRI-verified NAFLD, with no concurrent liver diseases. Randomization will be done to either a control diet, the 5:2 diet or a low-carb-high-fat diet. The subjects will follow the diet for three months, after which a new MRI is performed. Main outcomes measure is reduction in liver fat.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Known NAFLD
排除标准
- •Other forms of liver disease
- •Bolus insulin treatment
- •Cirrhosis
研究组 & 干预措施
Placebo
Placebo Comparator
Placebo diet
干预措施: Placebo diet (Behavioral)
5:2
Experimental
5:2 diet
干预措施: 5:2 diet (Behavioral)
LCHF
Experimental
LCHF diet
干预措施: LCHF (Behavioral)
结局指标
主要结局
Liver fat
时间窗: Three months
MRI-measured liver fat content
次要结局
未报告次要终点
研究者
Hannes Hagström
Primary Investigator
Karolinska University Hospital
研究点 (1)
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