Quantitative PET Imaging of Pancreatic Beta-cell Mass in Healthy and Type 1 Diabetic Patients With 18F-FP-DTBZ (AV-133)

Yale University1 site in 1 country16 target enrollmentAugust 2009

ConditionsDiabetes Mellitus, Type 1

Interventions18F-FP-DTBZ (18F-AV-133)Arginine-hydrochloride

Drugs18F-FP-DTBZ (18F-AV-133)

Overview

Phase: Not Applicable
Intervention: 18F-FP-DTBZ (18F-AV-133)
Conditions: Diabetes Mellitus, Type 1
Sponsor: Yale University
Enrollment: 16
Locations: 1
Primary Endpoint: PET-determined pancreatic islet beta-cell mass
Status: Completed
Last Updated: 13 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

Pancreatic Islet beta-cells are responsible for synthesizing and secreting appropriate amounts of insulin to regulate blood glucose levels. One factor in the development of diabetes is the loss of beta-cells. Developing treatments to prevent or restore islet beta-cell mass (BCM) in diabetic patients is hampered by a lack of methods for the non-invasive imaging of these cells. This study is designed to evaluate a radiolabeled compound that binds to the pancreatic islet. The investigators will test the ability of one promising imaging compound, 18F-9-fluoropropyl-(+)-dihydrotetrabenazine (18F-FP-DTBZ), to measure the amount of pancreatic islet beta-cells in patients with long-standing type-1 diabetes and in age-weight-matched healthy control subjects.

Registry

clinicaltrials.gov

Start Date

August 2009

End Date

May 2012

Last Updated

13 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Yale University

Responsible Party

Principal Investigator

Gary Cline

Associate Professor

Yale University

Eligibility Criteria

Inclusion Criteria

•Patients with Type 1 diabetes may be enrolled if they meet all of the following criteria:
•Have a diagnosis of Type 1 diabetes mellitus defined by ADA criteria or judgment of physician; diabetes onset younger than age 18, duration \>5 years
•Have fasting C-Peptide ≤ 0.1 ng/ml
•BMI between 18 and 29 kg/m2
•Able to tolerate PET and MR imaging
•No metal implants
•No claustrophobia
•Healthy volunteers may be enrolled if they meeting all of the following criteria:
•Have no history of Type 1 diabetes
•Fasting blood glucose ≤ 100 mg/dL

Exclusion Criteria

•Clinically significant renal dysfunction;
•Clinically significant liver dysfunction as determined by history, physical examination, and standard liver function testing at screening (AST, ALT, Total/Direct Bilirubin, Alkaline Phosphatase);
•Coagulopathy;
•History of allergic reactions to any drug
•Current use of any medications except for insulin for Type 1 diabetes
•Clinically significant cardiovascular disease or clinically significant abnormalities on screening ECG (including but not limited to QTc\>450 msec);
•Clinically significant psychiatric disease; Clinically significant pulmonary, renal or hepatic impairment or cancer, have clinically significant infectious disease, including AIDS or HIV infection, or previous positive test for hepatitis B, hepatitis C, HIV-1, or HIV-2; subjects will be asked about this. No testing will be performed.
•Have a history of alcohol or substance abuse or dependence;
•Are women of childbearing potential not refraining from sexual activity or not using adequate contraception. Women must not be pregnant (negative serum β-HCG at the time of screen) or lactating at screening, and must agree to take appropriate steps not to become pregnant during the study and for 30 days following the study.
•Currently receiving any investigational medications, or have participated in a trial with investigational medications within the last 30 days.