Brain waves during ventilatory response tests

Not Applicable

Recruiting

• Conditions: obstructive sleep apnea; Respiratory - Sleep apnoea

• Registration Number: ACTRN12612000454875
• Lead Sponsor: Dept of Respiratory and Sleep Medicine, RPA Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-04-23
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Healthy normal subjects and obstructive sleep apnea patients with apnea/hypopnea index (AHI)>15.

Exclusion Criteria

Sleep apnea patients: waking hypoxemia (oxygen saturation < 95%), BMI > 38 kg/m^2, severe COPD or other lung disease, uncontrolled cardiac disease
Normal subjects: No concurrent medical complaint including sleep apnea

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary outcome of interest is the potential relationship between the change of end tidal PCO2 and the change of EEG spectral power. (End tidal PCO2 is a key parameter measured during the ventilatory response tests using a fast response CO2 analyser.)[During the ventilatory response tests, baseline breathing room air phase compared with the hypercapnic phase of the single test session]

Secondary Outcome Measures

Name	Time	Method
Potential relationship between the change of PO2/SpO2 and the change of EEG spectral power. (PO2 is measured by a fast response O2 analyser during the venbtilatory response tests, and SpO2 is measured by an oxymeter using ear-clip sensor.)[During the ventilatory response tests, baseline breathing room air phase compared with the hypercapnic phase of the single test session];Potential difference in the pattern of change of EEG spectral power between normal subjects and sleep apnea patients in responding to hypercapnia and hypoxia.[The matching ventilatory response tests sessions]