Comparison the effect of oral oxycodone Vs oral meloxicam on pre-emptive control of postoperative pain after tonsillectomy in adults

Phase 2

Recruiting

Conditions: Tonsil hypertrophy.
Hypertrophy of tonsils
J35.1

Registration Number: IRCT20230926059532N1

Lead Sponsor: Mazandaran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 70

Inclusion Criteria

Patient willingness to participate in the study and gain informed consent
candidate for planned tonsillectomy with the indication of hypertrophy of tonsils, abnormal tonsil size, recurrent tonsillitis or previous tonsillitis
Age over 18 years
BMI between 18 and 35

Exclusion Criteria

Patient dissatisfaction
Age below 18 years
History of bleeding diseases
Renal failure
Liver failure
Chronic heart failure
History of drug abuse before surgery
History of long-term use of analgesics and NSAIDs regardless of the reason for its use
History of any allergy to opioids, codeine, acetaminophen, aspirin, NSAID
Any contraindications to the use of NSAIDs (such as peptic ulcer, asthma, angioedema, nasal polyps)
History of obstructive sleep apnea
Mental instability
Pregnancy
History of nasal polyps

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome of the comparison study of pain after surgery (yes/no). Timepoint: After surgery. Method of measurement: These outcomes are measured by an experienced nurse who does not know the assignment of the studied subjects to each of the two allocation groups. Pain level of patients based on NRS (Numeric Rating Scale).

Secondary Outcome Measures

Name	Time	Method
Secondary measurement of patients' pain intensity is based on NRS and the amount of use of painkillers. Timepoint: The pain level of patients based on NRS in minutes (0, 30, 60, minutes after reaching recovery and then 6, 12 and 24 hours after discharge from recovery) will be asked and recorded. Method of measurement: These outcomes are measured by an experienced nurse who does not know the allocation of the studied subjects to each of the two allocation groups. If the pain intensity is higher than 4 based on the NRS criteria, the patient is given intravenous acetaminophen one gram with a maximum limit of 4. grams per day and at least 6 hours between two doses, and the number of doses received will be recorded.