Influence of Exercise/Cardiorespiratory Fitness on Enhanced Endothelial Function With Aging: Role of Mitochondrial-derived Oxidative Stress
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Ball State University
- Enrollment
- 23
- Locations
- 1
- Primary Endpoint
- Change in vascular endothelial function
Study Overview
Brief Summary
The primary goal of this intervention is to determine the efficacy of acute mitochondrial-specific antioxidants to improve vascular endothelial function in middle-aged and older (≥45 y) adults who do no perform regular aerobic exercise. In a double-blind, randomized, placebo-controlled crossover design participants with receive both MitoQ and placebo arm of the study. Primary endpoints will include vascular endothelial function assessed by brachial artery flow-mediated dilation and cardiac function assessed via pulse wave analysis. Secondary endpoints will include measures of aortic stiffness assessed by carotid-femoral pulse wave velocity and carotid artery stiffness (e.g. β-stiffness) and elasticity (carotid compliance, distensibility, and Youngs elastic modulus) from ultrasonography.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Other
- Masking
- Double (Participant, Outcomes Assessor)
Masking Description
Double-blind, placebo-controlled
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Resting brachial blood pressure <160 mmHg (systolic)/<100 mmHg (diastolic)
- •Body mass index ≤ 35 kg/m2
- •Nonsmoker
- •Women must be postmenopausal defined as cessation of menses ≥ 1 year.
Exclusion Criteria
- •cardiovascular/metabolic medications
- •known clinical disease
- •absolute contraindications to exercise testing
Arms & Interventions
Placebo
Gelatin capsules
Intervention: Placebo (Dietary Supplement)
MitoQ
Capsules containing mitoquinone mesylate (MitoQ, 5 mg/capsule) totaling 80 mg were taken once.
Intervention: Mitoquinone Mesylate (Dietary Supplement)
Outcomes
Primary Outcomes
Change in vascular endothelial function
Time Frame: Baseline and Post 1 hour
Brachial artery flow-mediated dilation (% \[relative\] and mm \[absolute\])
Secondary Outcomes
- Change in carotid artery Young's elastic modulus(Baseline and Post 1 hour)
- Change in carotid artery compliance(Baseline and Post 1 hour)
- Change in carotid artery stiffness - beta-stiffness index(Baseline and Post 1 hour)
- Change in cardiovascular function(Baseline and Post 1 hour)
- Change in Aortic Stiffness(Baseline and Post 1 hour)
- Change in carotid artery distensibility(Baseline and Post 1 hour)
Investigators
Brad Fleenor
Associate Professor
Ball State University