Bananas as an Energy Source During Exercise: a Metabolomics Approach

Not Applicable

Completed

• Conditions: Intense Exercise
• Interventions: Dietary Supplement: Bananas versus 6% carbohydrate beverage

• Registration Number: NCT01581190
• Lead Sponsor: Appalachian State University

Brief Summary

This study compared the acute effect of ingesting bananas (BAN) versus a 6% carbohydrate drink (CHO) on 75-km cycling performance and post-exercise inflammation, oxidative stress, and innate immune function using traditional and metabolomics-based profiling.

Detailed Description

Trained cyclists (N=14) completed two 75-km cycling time trials (randomized, crossover) while ingesting BAN or CHO (0.2 g/kg carbohydrate every 15 min). Pre-, post-, and 1-h-post-exercise blood samples were analyzed for glucose, granulocyte (GR) and monocyte (MO) phagocytosis (PHAG) and oxidative burst activity, nine cytokines, F2-isoprostanes, ferric reducing ability of plasma (FRAP), and metabolic profiles using gas chromatography-mass spectrometry.

Study Timeline

• Study Start: 2011-09
• Primary Completion: 2011-11
• Study Completion: 2011-11
• Status Verified: 2012-04
• Study First Submitted: 2012-04-14
• Study First Submitted QC: 2012-04-18
• Last Update Submitted: 2012-04-18
• Study First Posted: 2012-04-20
• Last Update Posted: 2012-04-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 14

Inclusion Criteria

• Male
• Ages 18-45 years
• Cyclists, road racing experience.
• Willing to avoid the use of supplements, herbs, medications during the study.

Exclusion Criteria

• Female
• Over the age of 45 years
• No cycling racing experience
• Using supplements and medications during the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Bananas versus 6% carbohydrate beverage	Bananas versus 6% carbohydrate beverage	-

Primary Outcome Measures

Name	Time	Method
Performance and fuel substrate utilization as measured through metabolomics	Up to 6 months	Will measure shifts in metabolites following 75-km cycling while ingesting bananas or 6% carbohydrate beverage. The shift in metabolites will be assessed using GC-MS. Time frame from date of randomization until the last samples are collected and analyzed will be up to six months.

Secondary Outcome Measures

Name	Time	Method
Exercise-induced inflammation.	up to 6 months	Cytokine panel (IL-6, IL-8, IL-10, TNF-alpha) before and after cycling 75-km; measured with Meso Scale Discovery in pg/ml. Time frame from randomization until the last samples are collected and analyzed will be up to six months.

Trial Locations

Locations (1)

Human Performance Lab, North Carolina Research Campus; 🇺🇸 Kannapolis, North Carolina, United States