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临床试验/NCT03388411
NCT03388411已完成不适用

Nutritional Intake, Metabolic Abnormalities and Gut Microbiome in Children

Hallym University Kangnam Sacred Heart Hospital1 个研究点 分布在 1 个国家目标入组 61 人开始时间: 2017年10月18日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
61
试验地点
1
主要终点
Correlation of fecal microbial profile with childhood obesity

研究概览

简要总结

Pediatric obesity has been increasing in prevalence, but concerns have been raised around the world because no treatment has been found. Recently, however, research on gut microbiome has begun to become a new alternative. It has been shown that changes in the microbiome in adults may induce obesity. However, the results on children are still scarce. Unlike adults, children have few external factors such as alcohol, tobacco, stress, and cancer, making them suitable for obesity-related gut microbiome studies. The investigators will use Illumina MiSeq platform for 16s rRNA metagenomics profiling in children. In this study, the investigators aimed to analyze the relationship between pediatric obesity, gut microbiome profile, blood biomarkers relevant to metabolic syndrome, and nutrient intake data.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
— 至 12 Years(Child)
性别
All
接受健康志愿者

入选标准

  • Obese children: Children ≥95 ‰ between age 7 and 12 years
  • Non-obese children: 5‰<BMI <85 ‰ for children between the ages of 7 and 12 years

排除标准

  • Taking antibiotics, probiotics, or steroids for a month before visit
  • Taking probiotics-like products including yogurt for seven days before visit
  • Having enteritis symptoms including diarrhea for a month before visit
  • Chronic heart disease, chronic bowel disease, chronic liver disease, chronic kidney disease, endocrine disease, genetic diseases or congenital metabolic disorder

结局指标

主要结局

Correlation of fecal microbial profile with childhood obesity

时间窗: visit 1day

Analysis of fecal microbial profile using 16s rRNA sequencing

Correlation of fecal microbial profile with nutrient intake data using feeding diary

时间窗: visit 1day

Nutritional intake analysis of total calorie, carbohydrate, fiber, fat, and protein from feeding dairy for two days

次要结局

  • Correlation of childhood obesity with metabolic abnomalities using blood sampling(visit 1day)

研究者

发起方
Hallym University Kangnam Sacred Heart Hospital
申办方类型
Other
责任方
Principal Investigator
主要研究者

Ky Young Cho

Clinical Professor

Hallym University Kangnam Sacred Heart Hospital

研究点 (1)

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