Nutritional Intake, Metabolic Abnormalities and Gut Microbiome in Children
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Obesity, Childhood
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
- Enrollment
- 61
- Locations
- 1
- Primary Endpoint
- Correlation of fecal microbial profile with childhood obesity
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Pediatric obesity has been increasing in prevalence, but concerns have been raised around the world because no treatment has been found. Recently, however, research on gut microbiome has begun to become a new alternative. It has been shown that changes in the microbiome in adults may induce obesity. However, the results on children are still scarce. Unlike adults, children have few external factors such as alcohol, tobacco, stress, and cancer, making them suitable for obesity-related gut microbiome studies. The investigators will use Illumina MiSeq platform for 16s rRNA metagenomics profiling in children. In this study, the investigators aimed to analyze the relationship between pediatric obesity, gut microbiome profile, blood biomarkers relevant to metabolic syndrome, and nutrient intake data.
Investigators
Ky Young Cho
Clinical Professor
Hallym University Kangnam Sacred Heart Hospital
Eligibility Criteria
Inclusion Criteria
- •Obese children: Children ≥95 ‰ between age 7 and 12 years
- •Non-obese children: 5‰\<BMI \<85 ‰ for children between the ages of 7 and 12 years
Exclusion Criteria
- •Taking antibiotics, probiotics, or steroids for a month before visit
- •Taking probiotics-like products including yogurt for seven days before visit
- •Having enteritis symptoms including diarrhea for a month before visit
- •Chronic heart disease, chronic bowel disease, chronic liver disease, chronic kidney disease, endocrine disease, genetic diseases or congenital metabolic disorder
Outcomes
Primary Outcomes
Correlation of fecal microbial profile with childhood obesity
Time Frame: visit 1day
Analysis of fecal microbial profile using 16s rRNA sequencing
Correlation of fecal microbial profile with nutrient intake data using feeding diary
Time Frame: visit 1day
Nutritional intake analysis of total calorie, carbohydrate, fiber, fat, and protein from feeding dairy for two days
Secondary Outcomes
- Correlation of childhood obesity with metabolic abnomalities using blood sampling(visit 1day)