NCT01328132Unknown4 期
Effect of Hyperoncotic Albumin on Vascular Hemodynamics and Oxygen Delivery Following Orthotopic Liver Transplant
McGill University Health Centre/Research Institute of the McGill University Health Centre1 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2011年3月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Cardiac index (CI)
研究概览
简要总结
The primary aim of this study is to assess the effect of hyperoncotic albumin on vascular hemodynamics and oxygen delivery after orthotopic liver transplant. The secondary aim is to try to identify the dominant physiological mechanism so that we will be able to better identify patients that may benefit from the use of albumin (25%) boluses in addition to standard care in patients following liver transplantation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 years or older
- •Patients from the Critical care Unit
- •Patients with a pulmonary artery occlusion catheter Inclusion:patients immediately following liver transplantation
排除标准
- •Patients not giving informed consent
- •Patients who have received > 300 ml of albumin within 24 hours prior to inclusion
- •Patients known to have previous adverse reaction to human albumin solution
- •Patients who have religious restriction to receive human blood products
- •Patient who have initial graft failure
- •Patients with fluctuating hemodynamics
- •Concerns of the treating surgeon
研究组 & 干预措施
Saline
Active Comparator
干预措施: Saline (Drug)
25% albumin
Experimental
干预措施: 25% albumin (Drug)
结局指标
主要结局
Cardiac index (CI)
时间窗: 60 minutes after the infusion of the fluid
次要结局
- Cardiac function response(30 and 60 minutes after the infusion of the fluid)
- A decrease in leak and plasma expansion(30 and 60 minutes after the infusion of the fluid)
- Cardiac output response(30 and 60 minutes after the infusion of the fluid)
- Detoxification effect of albumin(30 and 60 minutes after infusion)
研究者
研究点 (1)
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