A study on the mechanism of auricular electroacupuncture on smoking cessation in young smokers

Early Phase 1

Conditions: icotine dependence

Registration Number: ITMCTR2024000155

Lead Sponsor: Shaanxi University of Traditional Chinese Medicine

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: Not specified

Inclusion Criteria

1. Inclusion criteria of smokers
1). Adult smokers who are willing to quit smoking, aged between 18 and 35 years old.
2) . Smokers with moderate or severe nicotine dependence, and FTCD=4.
3). Speak clearly and willing to finish MRI and EEG examination.
4). Willing to participate and provide signed informed consent.
5).Conforms to the diagnostic criteria of DSM-v.
6) Smokers who had not quit smoking within 3 months.
7). There were no contraindications to MRI scaning.
Note: smokers satisfy the above seven items at the same time will be included in this study.
2. Inclusion criteria of healthy non-smokers
1) No addiction history, no smoking or has smoked no more than 5 cigarettes in lifetime.
2) Aged between 18 and 35 years old, and the age and sex were matched with smoking participants.
3) Willing to participate and provide signed informed consent, and there were no contraindications to MRI scaning.
Note:non- smokers satisfy the above 3 items at the same time will be included in this study.

Exclusion Criteria

1. Exclusion critria of smoking participants
1). Smokers have a history of organic brain disease or craniocerebral injury history, coma.
2). Pregnant and lactating women
3). Smokers who have received pharmacological, psychobehavioral therapies or acupuncture for smoking cessation in last 3 months.
4). Patients who met DSM-5 diagnostic criteria for mental disorders within 3 generations, or long-term use of psychotropic drugs.
2. Exclusion criteria of non-smokers
1) Had a history of organic brain disease or craniocerebral injury and coma.
2) Pregnant and lactating women
3) Patients who met DSM-5 diagnostic criteria for mental disorders within 3 generations, or long-term use of psychotropic drugs
4) Nuclear magnetic resonance (NMR), electrical check contraindication
Notes: participants who meet the one of obove items will be excluded.