Exogenous Oxidation of Fructose-glucose Mixtures During Running

Not Applicable

Completed

• Conditions: Exercise
• Interventions: Dietary Supplement: Fructose-maltodextrin; Dietary Supplement: Fructose-maltodextrin hydrogel; Dietary Supplement: Glucose-maltodextrin

• Registration Number: NCT03731065
• Lead Sponsor: University of Bath

Brief Summary

The aim of this study is to characterise exogenous carbohydrate oxidation rates during exercise, when ingesting glucose (polymers) only, compared to glucose-fructose mixtures, and glucose-fructose mixtures ingested in hydrogel form.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-10-14
• Study First Submitted: 2018-11-02
• Study First Submitted QC: 2018-11-02
• Study First Posted: 2018-11-06
• Primary Completion: 2019-10-30
• Study Completion: 2019-11-30
• Status Verified: 2019-12
• Last Update Submitted: 2019-12-07
• Last Update Posted: 2019-12-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 9

Inclusion Criteria

• Maximal oxygen consumption > 50 ml.kg-1.min-1
• > 1 year training in endurance running or triathlon
• No current injury or injury within the last three months
• No history of cardiac or metabolic disease such as coronary heart disease or diabetes
• No current or history of gastrointestinal issues
• Successful completion of the physical activity readiness questionnaire (PAR-Q)

Exclusion Criteria

• Female
• Untrained in endurance running
• Current injury or injury within the past three months
• History of cardiac or metabolic disease such as coronary heart disease or diabetes
• History of or current gastrointestinal issues such as irritable bowel syndrome
• Unable to replicate diet and training for 3 and 5 days respectively prior to each experimental visit.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Fructose-maltodextrin ingestion	Fructose-maltodextrin	Ingestion of fructose and maltodextrin (glucose polymers) at a rate of 90 g carbohydrate per hour during two hours of treadmill running at 60%VO2peak.
Fructose-maltodextrin hydrogel ingestion	Fructose-maltodextrin hydrogel	Ingestion of fructose and maltodextrin (glucose polymers) encapsulated in alginate-pectin hydrogel, drinks at a rate of 90 g carbohydrate per hour during two hours of treadmill running at 60%VO2peak.
Glucose-maltodextrin ingestion	Glucose-maltodextrin	Ingestion of glucose and maltodextrin (glucose polymers) at a rate of 90 g carbohydrate per hour during two hours of treadmill running at 60%VO2peak.

Primary Outcome Measures

Name	Time	Method
Peak exogenous carbohydrate oxidation rate	120 minutes	Peak exogenous carbohydrate oxidation rate during 120 min of treadmill running. Measured using isotope ratio mass spectrometry and reported in grams per minute

Secondary Outcome Measures

Name	Time	Method
Ratings of gastrointestinal discomfort	120 minutes	Subjective ratings of gastrointestinal discomfort during 120 min of treadmill running. Measured using a 9-item questionnaire on a scale of 1 to 7, where 1 = No discomfort at all and 7 = very severe discomfort.; Items: Stomach; Heartburn; Acid reflux; Nausea; Rumbling; Bloated; Burping; Passing gas; Bowel movement.
Total fat oxidation	120 minutes	Total fat oxidation during 120 min of treadmill running. Measured using indirect calorimetry and reported in grams.
Plasma lactate concentrations	120 minutes	Plasma lactate concentrations during 120 min of treadmill running. Measured using colourimetric assay and reported in mmol/L.
Heart rate	120 minutes	Heart rate during treadmill running measured by telemetry and reported in beats per minute.
Plasma glucose concentrations	120 minutes	Plasma lactate concentrations during 120 min of treadmill running. Measured using colourimetric assay and reported in mmol/L.
Plasma non-esterified fatty acid concentrations	120 minutes	Plasma insulin concentrations during 120 min of treadmill running. Measured using colourimetric assay and reported in umol/L.
Total carbohydrate oxidation	120 minutes	Total carbohydrate oxidation during 120 min of treadmill running. Measured using indirect calorimetry and reported in grams.
Plasma insulin concentrations	120 minutes	Plasma insulin concentrations during 120 min of treadmill running. Measured using enzyme-linked immunosorbent assay and reported in pmol/L.
Ratings of perceived exertion	120 minutes	Subjective ratings of perceived exertion using the Borg scale (1982) during 120 min of treadmill running. Measured on a scale of 6 to 20, where 6 = no exertion at all, and 20 = maximal exertion.
Rate of oxygen consumption	120 minutes	Rate of oxygen consumption during 120 min of treadmill running. Measured using indirect calorimetry and reported in litres per minute.
Rate of carbon dioxide production	120 minutes	Rate of carbon dioxide production during 120 min of treadmill running. Measured using indirect calorimetry and reported in litres per minute.

Trial Locations

Locations (1)

Department for Health, University of Bath; 🇬🇧 Bath, United Kingdom