Contrast-enhanced Ultrasound for the Evaluation of Complex Renal Cysts
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Complex Renal Cyst
- Sponsor
- St. Joseph's Healthcare Hamilton
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- concordance between CEUS and CT
- Last Updated
- 4 years ago
Overview
Brief Summary
Complex renal cysts are often incidentally detected on imaging. The differential diagnosis of the complex renal cyst includes various benign cystic lesions, which are based on the Bosniak classification scheme. Currently the standard of care in evaluating a complex renal cyst is using a contrast-enhanced computed tomography (CT) scan, or a contrast-enhanced magnetic resonance imaging (MRI) scan. Since both of these modalities present adverse events due to frequent high doses of radiation, a technique such as a contrast-enhanced ultrasound (CEUS) can be used to obtain the same results, without having to impose high doses of radiation upon a patient.
Detailed Description
By evaluating complex renal cysts using a contrast-enhanced ultrasound (CEUS), it can be established as to whether or not the results are better, the same, or worse, when compared to CT and/or MRI scans.
Investigators
Anil Kapoor
MD, FRCSC
St. Joseph's Healthcare Hamilton
Eligibility Criteria
Inclusion Criteria
- •at least 18 years old and capable of giving informed consent
- •all patients undergoing CT evaluation of complex renal cysts at our centre (either initially or in follow-up)
- •A complex renal cyst defined as Bosniak IIF, III or IV
Exclusion Criteria
- •pregnant patients
- •patients with contrast allergies
- •patients with non-cystic, solid renal masses
- •patients with simple cysts (Bosniak class I and II)
Outcomes
Primary Outcomes
concordance between CEUS and CT
Time Frame: (Baseline, follow up at 3, 6, 9, & 12 months)
Complex renal cysts will be classified using the Bosniak classification system for both the CEUS and CT and compared. If surgical removal of a complex cyst is required (Bosniak IIF, III or IV), then the pathology will be evaluated with a single CEUS and a CT (The CEUS will be conducted 14 days within the CT).
Secondary Outcomes
- histopathological diagnosis after surgery of complex renal cysts(Baseline and every three months until the end of study.)
- Average percent difference of CEUS vs CT imaging(Baseline imaging (CEUS 14 days within a CT scan))