Cost-effectiveness analysis of intravenous propofol anesthesia versus inhalational Isoflurane anesthesia in patients undergo open surgery at Shahroud's Imam Hossein hospital.

Not Applicable

• Conditions: Condition 1: Calculus of gallbladder with acute cholecystitis. Condition 2: Anesthesia for appendectomy. Condition 3: Ventral hernia without obstruction or gangrene. Condition 4: Unilateral or unspecified inguinal hernia, without obstruction or gangrene. Condition 5: Abnormal uterine and vaginal bleeding, unspecified. Condition 6: Fracture of neck of femur. Condition 7: Fracture of lower leg, including ankle. Condition 8: Fracture of upper limb, level unspecified.; Calculus of gallbladder with acute cholecystitis; Acute appendicitis; Ventral hernia; Unilateral or unspecified inguinal hernia, without obstruction or gangrene; Abnormal uterine and vaginal bleeding, unspecified; Fracture of femur; Fracture of lower leg, including ankle; Fracture of upper limb, level unspecified

• Registration Number: IRCT2013022712123N2
• Lead Sponsor: Deputy of research, Shahroud University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Man or woman with 18 to 50 years old;an anesthesia risk of 1 or 2 (According to American society of anesthesiologist's classification); orthopedic or reconstructive operations on extremities; hip and pelvic operations;Inguinal hernioraphy; abdominal hernioraphy; cholecystectomy; appendectomy.
Exclusion criteria: Patients with a history of opiates or alcohol abuse; sedative and anticonvulsive therapy; anesthesia or surgical complications during operation

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
BIS (Depth of anesthesia). Timepoint: Every 5 minutes during operation. Method of measurement: By using Danmeter’s Cerebral State Monitor (Model CSM2) and record BIS index as an exact number from 0 to 100 every 5 minutes.;Heart rate. Timepoint: before procedure and every 5 minutes during operation. Method of measurement: Novin saadat's cardiac monitoring and record as beat per minute.;Systolic blood pressure. Timepoint: before procedure and every 5 minutes during operation. Method of measurement: Novin saadat's automatic Non invasive BP monitoring and record as mmHg.;Pupil's reflex. Timepoint: Every 5 minutes during operation. Method of measurement: Clinical observation and chart as Yes or No.;Pupil's size. Timepoint: every 5 minutes during procedure. Method of measurement: Clinical observation and chart as an exact number from 1 to 10 (milimeter).;Sweating. Timepoint: Every 5 minutes during operation. Method of measurement: Clinical observation and chart as Yes or No.

Secondary Outcome Measures

Name	Time	Method
Postoperative agitation. Timepoint: Every 5 minutes during recovery. Method of measurement: Clinical observation and chart as Yes or No.;Postoperative nausea and vomiting. Timepoint: Every 5 minutes during recovery. Method of measurement: Clinical observation and chart as Yes or No.;Recovery time. Timepoint: Every 5 minutes during recovery. Method of measurement: The end of recovery will be determined by Modified Alderet scoring system (MASS). In this system, scoring 9 points in 5 variables of consciousness, circulation (systemic blood pressure), breathing, SPO2, and activity, each of 2 points, specifies the end of recovery.;Postoperative pain. Timepoint: Every 5 minutes during recovery. Method of measurement: Clinical observation and chart as Yes or No.;Anesthesia cost. Timepoint: Time of discharge. Method of measurement: Total drug's (Isoflurane or Propofol) cost in Rial.