Pharmacogenomic Informed Statin Prescribing

Recruitment & Eligibility

Status: Not yet recruiting

Sex: All

Target Recruitment: 410

Inclusion Criteria

Inclusion Criteria: Patients will be included in the analysis if they: - Are a Veteran - Aged 40-75 years - Diabetes mellitus or cardiovascular disease (coronary, cerebral, or peripheral artery disease) - An upcoming primary care appointment in the next 4 months - No active statin prescription (any time/dose, VA, or non-VA) in the prior 6 months - English speaking - At least 1 current active VA prescription - At least 1 primary care appointment within the prior 2 years Exclusion Criteria: - Non-Veterans - End-stage renal disease - History of rhabdomyolysis - Active treatment for non-dermatologic cancer - Known, prior SLCO1B1 genetic test results - Liver cirrhosis - Palliative care or hospice in 1-year prior to admission, during hospital stay, or at discharge - Active prescription for PCSK9 inhibitor - Inability to provide informed consent due to language impairment, cognitive disease, or other similar factors at the discretion of the research assistant or project coordinator. - Active enrollment in a different, interventional clinical trial, at the discretion of PI. - History of allogeneic stem cell transplant or liver transplant. - Documentation of specific adverse drug reactions thought to be attributed to statins: - Myopathy with associated elevation in creatinine kinase > 10x upper limit of normal - Angioedema - Elevated AST/ALT - Others at discretion of PI

Exclusion Criteria

Not provided

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in low density lipoprotein cholesterol

Secondary Outcome Measures

Name	Time	Method

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