Risk Factors of liver disease in the family of Liver disease patient.
Not Applicable
- Conditions
- Health Condition 1: K760- Fatty (change of) liver, not elsewhere classifiedHealth Condition 2: K769- Liver disease, unspecified
- Registration Number
- CTRI/2019/08/020780
- Lead Sponsor
- Institute of Liver and Biliary Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Diagnosed cases of NASH with Cirrhosis.
2.Age >= 8 year
3.All the first degree relatives of NRC i.e index case.
4.Subject with no history of any known liver disease
5.Non-Alcoholic
6.Matched with age (+/-5 years) and gender
Exclusion Criteria
1.Acute on Chronic Liver Failure
2.Patients with HBV, HCV, Wilson, Hemochromatosis, alpha 1 antitrypsin deficiency, primary biliary cirrhosis).
3.Patient on amiodarone or tamoxifen or methotrexate.
4.Patient of malignancies other than liver.
5.Patient on chemotherapy
6.HBV related Liver Fibrosis (<= F3).
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Assessment of the risk factors for liver fibrosis among the first degree relatives of NASH related CirrhosisTimepoint: 0 day
- Secondary Outcome Measures
Name Time Method Assessment of the risk factors in patients with NASH related cirrhosis and Hepatitis B Virus Control.Timepoint: 0 day;Assessment of the risk factors in patients with NASH related Cirrhosis and their Healthy Control.Timepoint: 0 day;To assess the Genetic Single Nucleotide Polymorphism in NASH related Cirrhosis patients and their first degree relatives.Timepoint: 0 day;To assess the proportion of Liver fibrosis among first degree relatives of patients with NASH related Cirrhosis.Timepoint: 0 day