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Clinical Trials/EUCTR2015-001129-17-LT
EUCTR2015-001129-17-LT
Active, not recruiting
Phase 1

A multicenter, open-label study to investigate the effectiveness and safety of AOP Landiolol in controlling supraventricular tachycardia in pediatric patients (LANDI-PED). - LANDI-PED

AOP Orphan Pharmaceuticals AG0 sites60 target enrollmentFebruary 20, 2020

Overview

Phase
Phase 1
Intervention
Not specified
Conditions
Supraventricular tachycardia in pediatric patients.
Sponsor
AOP Orphan Pharmaceuticals AG
Enrollment
60
Status
Active, not recruiting
Last Updated
4 years ago

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
February 20, 2020
End Date
TBD
Last Updated
4 years ago
Study Type
Interventional clinical trial of medicinal product
Sex
All

Investigators

Eligibility Criteria

Inclusion Criteria

  • 1\. Informed consent/assent from parents/legal representative(s) and children, if applicable.
  • 2\. Age: from birth to the day before the 18th birthday.
  • 3\. Body weight at least 2\.5 kg.
  • 4\. Sustained supraventricular tachyarrhythmia for more than 1 min.
  • 5\. If sub\-type paroxysmal supraventricular tachycardia (AVRT, AVNRT), refractory to treatment with adenosine, adenosine treatment relapsers and patients with contraindications to adenosine; or other forms of paroxysmal SVT not indicated for adenosine.
  • Are the trial subjects under 18? yes
  • Number of subjects for this age range: 60
  • F.1\.2 Adults (18\-64 years) no
  • F.1\.2\.1 Number of subjects for this age range 0
  • F.1\.3 Elderly (\>\=65 years) no

Exclusion Criteria

  • 1\. Acute cardiogenic shock.
  • 2\. Severe, uncorrectable metabolic acidosis.
  • 3\. Ventricular tachycardia.
  • 4\. Sick sinus syndrome (if there is no possibility for cardiac pacing) or clinically significant bradycardia.
  • 5\. Acute asthma.
  • 6\. Known pulmonary hypertension
  • 7\. Known stage 4 and 5 chronic renal disease (Table 7\).
  • 8\. AV block 2nd or 3rd degree (if there is no possibility for cardiac pacing).
  • 9\. Clinically significant hypotension.
  • 10\. Postmenstrual age (gestational age \+ chronological age) \<37 weeks

Outcomes

Primary Outcomes

Not specified

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