Comparison of effect of vitamin E vaginal cream with vaginal estradiole on atrophic vaginitis among menopausal women.

Phase 2

Conditions: Atrophic Vaginitis.
Senile (atrophic) vaginitis
N95.2

Registration Number: IRCT20150424021917N12

Lead Sponsor: Tabriz University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: Female

Target Recruitment: 72

Inclusion Criteria

Physiologic menopause women
Having sexual activity
Affected by atrophic vaginitis(having 3 signs out of 5 signs)
Affected by over active bladder syndrome (score 3 of the OABSS questionnaire)

Exclusion Criteria

Vaginal bleeding
Hormone replacement therapy during last 3 months
History of breast cancer or any type of estrogen dependent cancer
History of breast cancer in first grade relatives (ex. mother, sister)
Estrogen contraindications include a history of gallstones, a history of venous thrombosis, any type of vascular disease, the presence of thrombophlebitis.
Taking anticoagulants

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Score of symptoms of atrophic vaginitis. Timepoint: Vaginal symptoms score will be measured before and 8 weeks after the start of the intervention. Method of measurement: For evaluation of this variable we will use of standard questionnaire.

Secondary Outcome Measures

Name	Time	Method
Score of symptoms of overactive bladder syndrome. Timepoint: Score of symptoms of overactive bladder syndrome will be measured before and 8 weeks after the start of the intervention. Method of measurement: A standard questionnaire is used to measure this variable.;Satisfaction score. Timepoint: Satisfaction score of the drug will be measured 8 weeks after the start of the intervention. Method of measurement: A standard questionnaire is used to measure this variable.;Frequency of side effects. Timepoint: frequency of side effects, will be measured 8 weeks after the start of the intervention. Method of measurement: A standard questionnaire is used to measure this variable.