Echocardiographic Evaluation of Hypertensive Acute Pulmonary Edema
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 51
- 试验地点
- 1
- 主要终点
- acute myocardial dysfunction (systolic and diastolic) and/or dyssynchrony
研究概览
简要总结
Acute cardiogenic pulmonary edema (ACPE), one of the most severe forms of acute heart failure, represents 5% of hospital admissions. One of the most frequent phenomena encountered during ACPE is hypertensive crisis (hypertensive ACPE) but the mechanisms and causes of hypertensive ACPE are insufficiently understood. Few studies have evaluated the cardiac function during hypertensive ACPE, and these studies used only conventional echocardiography methods. New methods of evaluation of cardiac function in hypertensive ACPE (such as Tissue Doppler imaging) have not been used.
The objectives of this study are to evaluate presence and role of the following potential mechanisms of hypertensive ACPE: 1. acute myocardial dysfunction (systolic and diastolic); 2. silent transient myocardial ischemia; 3. acute mechanical left ventricular dyssynchrony; 4. dynamic mitral regurgitation; 5. inter-ventricular interaction. Conventional and Tissue Doppler echocardiography will be used to assess cardiac function.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •acute onset of dyspnea within the preceding 8 hours
- •respiratory distress and pulmonary rales at any level
- •pulmonary congestion confirmed by chest radiography
- •systolic blood pressure > 160 mmHg before treatment
- •sinus rhythm
- •signed informed consent
- •Exclusion criteria:
- •acute myocardial infarction confirmed by myocardial necrosis markers (either CKMB or troponin I). Angina pectoris alone will not be excluded
- •significant left sided valvular disease (more than moderate). Mitral regurgitation of any severity will not be excluded, due to the hypothesis of the role of dynamic mitral regurgitation in the pathogenesis of acute hypertensive pulmonary edema
- •congenital heart disease
- •cardiac tamponade
- •rhythm and conduction disturbances that may have precipitated pulmonary edema, like sustained ventricular tachycardia and complete heart block
排除标准
- 未提供
结局指标
主要结局
acute myocardial dysfunction (systolic and diastolic) and/or dyssynchrony
时间窗: acute event and 48 to 96 h after the event
次要结局
- surrogate markers of silent transient myocardial ischemia(acute event and 48 to 96 h after the event)
- dynamic mitral regurgitation(acute event and 48 to 96 h after the event)
- inter-ventricular interaction(acute event and 48 to 96h after the event)
研究者
Mircea Cinteza
Professor
Carol Davila University of Medicine and Pharmacy