MedPath

Protect II, A Prospective, Multicenter Randomized Controlled Trial

Phase 3
Terminated
Conditions
Coronary Artery Disease
Interventions
Device: IMPLELLA LP 2.5
Device: IABP Intra-aortic balloon pump
Registration Number
NCT00562016
Lead Sponsor
Abiomed Inc.
Brief Summary

The IMPELLA® 2.5 System will be superior to Intra Aortic Balloon Pump in preventing the composite rate of major adverse events during and after the PCI procedure.

Detailed Description

Not available

Recruitment & Eligibility

Status
TERMINATED
Sex
All
Target Recruitment
452
Inclusion Criteria
  • Informed consent

  • Subject is indicated for a NON emergent percutaneous treatment of at least on de novo or restenotic lesion in a native coronary vessel or bypass graft.

  • Patient presents with:

    • A compromised Ejection Fraction
    • Intervention on the last patent coronary conduit
    • Intervention on an unprotected left main artery or
    • Patient presenting with triple vessel disease.
Exclusion Criteria
  • ST elevation M.I.
  • Pre procedure cardiac arrest within 24 hours.
  • Subject in cardiogenic shock

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
IMPELLA LP 2.5IMPLELLA LP 2.5-
IABP Intra-aortic balloon pumpIABP Intra-aortic balloon pump-
Primary Outcome Measures
NameTimeMethod
Composite rate of 10 major adverse events including death; MI;Stroke or TIA; and repeat revascularization.30 days +/- 10 days
Secondary Outcome Measures
NameTimeMethod
Maximum CPO decrease from baseline.Rate of in hospital major events compared between the IMPELLA and IABP.In hospital events

Trial Locations

Locations (50)

Emory Crawford Long Hospital

🇺🇸

Atlanta, Georgia, United States

Loyola University Medical Center

🇺🇸

Maywood, Illinois, United States

Bryan LGH Heart Institute

🇺🇸

Lincoln, Nebraska, United States

Toronto General Hospital

🇨🇦

Toronto, Ontario, Canada

Massach General Hospital

🇺🇸

Boston, Massachusetts, United States

St. Elizabeths Medical Center

🇺🇸

Boston, Massachusetts, United States

Methodist Hospital

🇺🇸

Houston, Texas, United States

University of Texas Medical School at Houston

🇺🇸

Houston, Texas, United States

University of Miami

🇺🇸

Miami, Florida, United States

York Hospital

🇺🇸

York, Pennsylvania, United States

University of Washington

🇺🇸

Seattle, Washington, United States

Medical College Of Georgia

🇺🇸

Augusta, Georgia, United States

Foundation for Cardiovascular Medicine

🇺🇸

La Jolla, California, United States

University of Chicago Medical Center

🇺🇸

Chicago, Illinois, United States

California Cardiovascular/Washington Hospital

🇺🇸

Fremont, California, United States

Mt. Sinai School of Medicine

🇺🇸

New York, New York, United States

Columbia Presbyterian Hospital

🇺🇸

New York,, New York, United States

Carolinas Medical Center

🇺🇸

Charlotte, North Carolina, United States

University of Southern California

🇺🇸

Los Angeles, California, United States

St. Joseph's Hospital

🇺🇸

Bellingham, Washington, United States

Riverside Methodist

🇺🇸

Columbus, Ohio, United States

Veteran's Affairs Medical Center Dallas

🇺🇸

Dallas, Texas, United States

Henry Ford Medical

🇺🇸

Detroit, Michigan, United States

University of Alabama

🇺🇸

Birmingham, Alabama, United States

Banner Good Samaritan Medical Center

🇺🇸

Phoenix, Arizona, United States

Harper Hospital

🇺🇸

Detroit, Michigan, United States

St. John Hospital and Medical Center

🇺🇸

Detroit, Michigan, United States

Duke University Medical Center

🇺🇸

Durham, North Carolina, United States

Cardiovascular Research of Forsythe Medical

🇺🇸

Winston-Salem, North Carolina, United States

University of Cincinnati

🇺🇸

Cincinnati, Ohio, United States

Brigham & Womens

🇺🇸

Boston, Massachusetts, United States

Washington Adventist Hospital

🇺🇸

Takoma Park, Maryland, United States

Northern Michigan

🇺🇸

Petoskey, Michigan, United States

St. Louis University

🇺🇸

St. Louis, Missouri, United States

UPMC Presbyterian Hospital

🇺🇸

Pittsburgh, Pennsylvania, United States

Strong Memorial Hospital

🇺🇸

Rochester, New York, United States

Robert Packer Hospital

🇺🇸

Sayre, Pennsylvania, United States

Pinnacle Health

🇺🇸

Wormleysburg, Pennsylvania, United States

Intermountain Medical Center

🇺🇸

Murray, Utah, United States

Mercy Gilbert Medical Center

🇺🇸

Gilbert, Arizona, United States

William Beaumont

🇺🇸

Royal Oak, Michigan, United States

Morristown Memorial

🇺🇸

Morristown, New Jersey, United States

Royal Alexandra Hospital

🇨🇦

Edmonton, Alberta, Canada

Ottawa Heart Institute

🇨🇦

Ottawa, Ontario, Canada

Providence Hospital and Medical Centers

🇺🇸

Southfield, Michigan, United States

Royal Victoria Hospital at McGill

🇨🇦

Montreal, Quebec, Canada

Academic Medical Center

🇳🇱

Amsterdam, Netherlands

Munroe Regional Medical Center

🇺🇸

Ocala, Florida, United States

University of Alberta Hospital

🇨🇦

Edmonton, Alberta, Canada

Oakwood Hospital Wayne State University

🇺🇸

Dearborn, Michigan, United States

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