NCT02051114进行中（未招募）不适用
Discovering the Antecedents of Rheumatoid Arthritis Flare
适应症
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- RNA transcripts that correlate with rheumatoid arthritis disease activity
研究概览
简要总结
Longitudinal study of patients with rheumatoid arthritis comparing measures of disease activity with blood samples.
详细描述
80% of patients living with rheumatoid arthritis can expect fluctuations in their symptoms over time. Dramatic increases in disease activity are considered flare. This study will follow patients with increased risk for flare prospectively for one year. Serial questionnaires and disease activity scores will be compared to blood samples to better understand the molecular phenotype of rheumatoid arthritis flares.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •2010 criteria for Rheumatoid Arthritis
- •Swelling of at least one joint and or elevated acute phase reactants
- •Greater than or equal to 40 years old or less than or equal to 65 year old female sex
- •cyclic citrullinated peptide antibody + in the past 12 months
排除标准
- •hemoglobin < 9
- •white blood cell count < 3.5
- •Diagnosis of any active malignancy within the last 3 years besides non-melanomatous skin cancer
- •Diagnosis of diabetes and requires insulin
- •HIV+, Hep B S Ag+, Hep C polymerase chain reaction +
- •Untreated latent tuberculosis
- •Diagnosis of any additional systemic autoimmune connective tissue disease
- •Inability to reliably complete study requirements
- •History, physical, social or laboratory findings suggestive of any other medical or psychological condition that would, in the opinion of the principal investigator, make the candidate ineligible for the study
结局指标
主要结局
RNA transcripts that correlate with rheumatoid arthritis disease activity
时间窗: 1 year
Blood drawn at various times throughout one year will be correlated with fluctuations in RA disease activity.
次要结局
未报告次要终点
研究者
研究点 (1)
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