Risk of Malignancy in Endemic Long Standing Nodular Goitres: a Prospective Cohort Study

Completed

• Conditions: Incidence of Thyroid Cancer in Long Standing MNG

• Registration Number: NCT06405919
• Lead Sponsor: University of Khartoum

Brief Summary

To determine the incidence of thyroid cancer in patients with long standing goitres presenting for surgery.

Detailed Description

This is a prospective cohort study The objective is to determine the incidence of cancer in patients with long standing goitres( more than 10 years ) who present for surgery in Khartoum Teaching Hopspital - Sudan.

Introduction: goitre is endemic in Sudan with prevalence ranging between 5-42% in different regions of the country. Patients are referred for surgery only if they develop pressure symptoms.

The incidence of thyroid carcinoma is high in endemic goitrous areas. Determining the risk of cancer in patient with long standing goitres may help in early early referral and early surgical intervention.

Methods: This is prospective cohort study including 160 patients with long standing goitrers of 10 years or more who presented from March 2017 to September 2017 to Khartoum Teaching Hospital-Sudan

Study Timeline

• Study Start: 2017-03-01
• Primary Completion: 2018-09-30
• Study Completion: 2018-09-30
• Status Verified: 2024-05
• Study First Submitted: 2024-05-04
• Study First Submitted QC: 2024-05-04
• Last Update Submitted: 2024-05-04
• Study First Posted: 2024-05-09
• Last Update Posted: 2024-05-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

• All patients with long standing goitres of 10 years or more

Exclusion Criteria

• Non

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Rate of malignancy	March 2017-September 2018	Rate of malignancy in resected goitre specimens

Trial Locations

Locations (1)

Faculty of Medicine University of Khartoum; 🇸🇩 Khartoum, Sudan