How does the anti-sickness drug dexamethasone influence the immune function in healthy volunteers?

Phase 4

Completed

• Conditions: Immune function; Anaesthesiology - Anaesthetics; Inflammatory and Immune System - Normal development and function of the immune system

• Registration Number: ACTRN12609000903280
• Lead Sponsor: Clinical A/Professor Tomas Corcoran

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-10-19
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

Healthy volunteers in American Society of Anaesthesiologists Classification (ASA) I-II

Exclusion Criteria

1.Current drug therapy with antiemetics, steroids or serotonergic antidepressants 2.Active infection known or suspected metastatic disease
3.Previous chemotherapy treatment 4.Allergy/intolerance to any of the study drugs (including renal or hepatic impairment, active peptic ulcer disease, ischaemic heart disease, QT prolongation, major psychiatric illness)
5.Diabetes mellitus or history of seizures 6.Participation in any other research trial 7.Pregnant or possibility of

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Proportions of lymphocyte subpopulations on blood analysis[Baseline, 4 hours, 24 hours and 168 hours after administration of drug]

Secondary Outcome Measures

Name	Time	Method
Serum Macrophage Inhibitory Factor concentrations[Baseline, 4 hours, 24 hours and 168 hours after administration of drug]