Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's Disease
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 721
- Locations
- 1
- Primary Endpoint
- The amount of brain amyloid deposition
Study Overview
Brief Summary
This is a prospective cohort study for cognitively normal (young and old), mild cognitive impairment, and Alzheimer's disease people
Detailed Description
The aim of the study is 1) to search new biomarkers and develop clinically applicable early diagnosis and prediction methods of Alzheimer's disease, and 2) to investigate how the proposed lifetime risk and protective factors for Alzheimer's disease contribute to pathological hallmarks of AD or other brain changes in living human through annual comprehensive clinical and neuropsychological evaluation and biannual brain imaging (MRI and MRA, Fluorodeoxyglucose(FDG)-PET, Pittsburgh compound B (PiB)-PET), AV--1451 PET, and body specimen (blood, gene, and hair) analysis.
* Note: AV-1451 PET will not be applied to whole subjects, but to 210 subjects (30 young CN, 60 old CN, 60 MCI, and 60 AD).
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 20 Years to 90 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
The amount of brain amyloid deposition
Time Frame: baseline
Group difference in baseline brain amyloid deposition (on PIB PET) and the relationship between the amount of brain amyloid deposition and clinical, neuropsychological, neuroimaging, genetic, biochemical measurement will be investigated.
Secondary Outcomes
- Group difference for each clinical, neuropsychological, structural and functional neuroimaging, tau imaging, genetic, biochemical measures(baseline)
- Change of clinical, neuropsychological measures(baseline, 1yr, 2yr,3yr, 4yr)
- Change of brain amyloid deposition(baseline, 2yr, 4yr)
- Change of structural and functional neuroimaging measures(baseline, 2yr, 4yr)
- Change of biochemical measures(baseline, 2yr, 4yr)
- Chage of tau imaging measures(2yr, 4yr)
Investigators
Dong Young Lee
professor
Seoul National University Hospital