Optimization of 18F-choline PET/CT Acquisition in Prostate Cancer: Preliminary Results Concerning the Length of the Acquisition
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Prostate Cancer
- Sponsor
- University Hospital, Brest
- Enrollment
- 61
- Locations
- 1
- Primary Endpoint
- correlation between Gleason score and dynamic parameters on PET and MRI
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Prostate cancer is the most common cancer in men over 50 years old and the third leading cause of cancer death. Because of the variety of prostate cancers, different treatments exist.
Several criteria guide this management in daily practice: PSA level; TNM stage (digital rectal examination, trans-rectal ultrasound and classical visual imaging) and pathological differentiation with the Gleason score, to which can be added other prognostic criteria: growth and doubling time of the serum PSA, number of positive biopsies and percentage of cancer lesions by biopsy.
Functional imaging by PET and MRI is increasingly used in daily clinical practice to characterize prostate cancer, either during initial discovery or during recurrence. In this context, it is the qualitative visual analysis that is mainly used. Quantitative image analysis could add new criteria to guide patient management.
Consequently, the objective of this study were:
- Optimization of 18F-choline PET/CT Acquisition in Prostate Cancer
- Comparison the quantitative parameters obtained by 18F-Choline PET / CT and both perfusion MRI and histological parameters.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients with prostate cancer histologically proven included in Brest University Hospital between 01/07/2012 and 01/10/2015 and underwent F-choline PET/CT and pelvic MRI Patient consent
Exclusion Criteria
- •No lesion on dynamic acquisition on PET/CT and/or on pelvic MRI
Outcomes
Primary Outcomes
correlation between Gleason score and dynamic parameters on PET and MRI
Time Frame: when anatomopathological report is available, an average of 3 months after the PET/CT
study the potential correlation between dynamic parameters on PET and MRI
Secondary Outcomes
- reconstructions on 18F-choline PET(when all 18F-choline PET are performed, an average of 6 months)
- best "fitting" on PET and MRI(when all MRI are performed, an average of 6 months)
- comparison between data (PSA, TNM stage, EFS and OS)(01/05/2017)