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Study of CD07805/47 Topical Gel in Subjects With Facial Erythema Associated With Rosacea

Phase 3
Completed
Conditions
Rosacea
Interventions
Drug: CD07805/47 gel 0.5%
Registration Number
NCT01318733
Lead Sponsor
Galderma R&D
Brief Summary

A long-term, open-label, non-comparative safety and efficacy study of CD07805/47 gel 0.5% once daily in subjects with moderate to severe facial erythema associated with rosacea.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
449
Inclusion Criteria
  • Male or female who is at least 18 years of age or older.
  • A clinical diagnosis of facial rosacea.
  • A Clinician Erythema Assessment (CEA) score of ≥3 at Screening and at Baseline (prior to study drug application).
  • A Patient Self Assessment (PSA) score of ≥3 at Screening and at Baseline (prior to study drug application).
Exclusion Criteria
  • Particular forms of rosacea (rosacea conglobata, rosacea fulminans, isolated rhinophyma, isolated pustulosis of the chin) or other concomitant facial dermatoses that are similar to rosacea such as peri-oral dermatitis, demodicidosis, facial keratosis pilaris, seborrheic dermatitis, acute lupus erythematosus, or actinic telangiectasia.
  • Current diagnosis of Raynaud's syndrome, thromboangiitis obliterans, orthostatic hypotension, severe cardiovascular disease, cerebral or coronary insufficiency, renal or hepatic impairment, scleroderma, Sjögren's syndrome, or depression.
  • Previous refractive eye surgery such as photorefractive keratectomy (PRK), laser-assisted sub-epithelial keratectomy (LASEK), or laser-assisted in situ keratomileusis (LASIK).
  • Current treatment with monoamine oxidase (MAO) inhibitors.
  • Current treatment with barbiturates, opiates, sedatives, systemic anesthetics, or alpha-agonists.
  • Less than 3 months stable dose treatment with tricyclic anti-depressants, cardiac glycosides, beta blockers or other antihypertensive agents.

Study & Design

Study Type
INTERVENTIONAL
Study Design
SINGLE_GROUP
Arm && Interventions
GroupInterventionDescription
CD07805/47 Gel 0.5%CD07805/47 gel 0.5%-
Primary Outcome Measures
NameTimeMethod
Long Term Safety & Efficacy of CD07805/47 Gel 0.5% in Subjects With Moderate to Severe Facial Erythema Associated With Rosacea.Over 1 year

Static evaluation of erythema severity using the Clinician Erythema Assessment (CEA) - Grade/Description 0 / Clear Skin with no signs of erythema

1. / Almost clear; slight redness

2. / Mild erythema; definite redness

3. / Moderate erythema; marked redness

4. / Severe erythema; fiery redness

Change in CEA from Baseline CEA (T0 at Baseline visit Day 1) at T3 of each post-baseline visit, including Day 1.

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (27)

DermResearch Center of New York, Inc

🇺🇸

Stony Brook, New York, United States

Rivergate Dermatology Clinical Research Center, PLLC

🇺🇸

Goodlettsville, Tennessee, United States

Wenatchee Valley Medical Center - Clinical Research Department

🇺🇸

Wenatchee, Washington, United States

Dermatology Clinical Research Center of San Antonio

🇺🇸

San Antonio, Texas, United States

Progressive Clinical Research, PA

🇺🇸

San Antonio, Texas, United States

Gwinnett Clinical Research Center, Inc

🇺🇸

Snellville, Georgia, United States

Wilmington Medical Research

🇺🇸

Wilmington, North Carolina, United States

East Tennessee Medical Research

🇺🇸

Johnson City, Tennessee, United States

Cherry Creek Research, Inc

🇺🇸

Denver, Colorado, United States

The Laser Institute for Dermatology

🇺🇸

Santa Monica, California, United States

Compliant Clinical Research

🇺🇸

Olathe, Kansas, United States

Dermatology, Laser & Vein Specialists of the Carolinas

🇺🇸

Charlotte, North Carolina, United States

Palmetto Medical Research

🇺🇸

Mount Pleasant, South Carolina, United States

Madison Skin & Research, Inc.

🇺🇸

Madison, Wisconsin, United States

Hamzavi Dermatology

🇺🇸

Fort Gratiot, Michigan, United States

TriCities Medical Research

🇺🇸

Kingsport, Tennessee, United States

Metrolina Medical Research

🇺🇸

Charlotte, North Carolina, United States

Longmont Clinical PC

🇺🇸

Longmont, Colorado, United States

Deaconess Clinic

🇺🇸

Evansville, Indiana, United States

Dermcenter PC- Somerset Skin Centre

🇺🇸

Troy, Michigan, United States

Minnesota Clinical Study Center

🇺🇸

Fridley, Minnesota, United States

Piedmont Medical Research

🇺🇸

Winston-Salem, North Carolina, United States

Tennessee Clinical Research Center

🇺🇸

Nashville, Tennessee, United States

DermDox

🇺🇸

Hazleton, Pennsylvania, United States

Arlington Center for Dermatology

🇺🇸

Arlington, Texas, United States

Dermatology Research Center

🇺🇸

Salt Lake City, Utah, United States

Skin Specialists, PC

🇺🇸

Omaha, Nebraska, United States

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