Safety and efficacy of single-dose and triple-dose albendazole and mebendazole against soil-transmitted helminth infections in humans

Completed

• Conditions: Soil-transmitted helminth infections (Ascaris lumbricoides, Trichuris trichiura, hookworms); Infections and Infestations; Other helminthiases

• Registration Number: ISRCTN47375023
• Lead Sponsor: Swiss Tropical Institute (STI) (Switzerland)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2008-11-28
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 370

Inclusion Criteria

1. Age: greater than or equal to 5 years old
2. Sex: males and females
3. Residency: resident of Nongyang village in Menghai county, Yunnan province, People?s Republic of China
4. Registration, participation: signing of written informed consent sheet (5 - 17 year olds: additional written approval by parents or legal guardians), willingness to comply with study procedures (stool submission, drug treatment, alcohol abstinence at day of treatment)
5. Absence of systemic or chronic diagnosed or perceivable illness as assessed by medical personnel upon enrolment and again at each day of treatment
6. Females: not pregnant (as verbally assessed by female medical personnel upon enrolment and again at each day of treatment)

Exclusion Criteria

1. Age: less than 5 years
2. Residency: not a permanent resident of Nongyang village in Menghai county, Yunnan province, People?s Republic of China
3. Registration, participation: no written informed consent sheet signed or parental approval not obtained, unwillingness to comply with all study procedures
4. Presence or suspicion of any abnormal medical condition which is known or suspected to interfere with anthelminthic treatment
5. Known hypersensitivity to any anthelminthic drugs
6. Recent history of anthelminthic treatment
7. Current or past (within 1 month) participation in any other medical trial
8. For females: suspected or verified pregnancy

Study & Design

• Study Type: Interventional
• Study Design: Not specified