Motor learning in Parkinson*s disease: a randomised comparison of integrated and consecutive task gait practice

Phase 3

Recruiting

Conditions: neurologische aandoening: ziekte van Parkinson
Parkinson's disease

Registration Number: NL-OMON37534

Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

1) Diagnosis of Parkinson's disease based on UK Brain Bank criteria;
2) Hoehn & Yahr stage II-III in the on-phase;
3) Able to walk for 10 minutes continuously (FAC>4 *);
4) Dual task interference of at least 5% using a cognitive secondary task;
5) Without cognitive impairment (MoCA > 24+MMSE>24);
6) On stable medication;;* M.K. et al. (1984)
Functional Ambulation Category 4: Patient can walk independently on level ground, but requires help on stairs, slopes or uneven surfaces.

Exclusion Criteria

1) Deep Brain stimulation; not an exclusion criteria when it is placed longer than a year ago and a stable result is being accomplished.
2) Severe medical conditions affecting gait;
3) Hearing and severe visual problems affecting testing;
4) Likely to change medication regimen;
5) Already receiving dual task training from their physiotherapist;

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary outcome measure is Dual Task (DT) gait performance. DT gait performance<br /><br>will be evaluated by measuring gait speed at maximum levels while performing<br /><br>untrained cognitive tasks. At baseline, the appropriate cognitive task<br /><br>(sufficient level of cognitive challenge for each patient) will be determined </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>• Cognitive performance during dual task walking; amount of errors are scored<br /><br>during the dual task assessment on the walkway.<br /><br>• Gait performance during the trained cognitive tasks; as measured by the<br /><br>GAITRite system.<br /><br>• Dual task interference outcomes; by comparing the gait performance on the<br /><br>single task and dual task assessment.<br /><br>• Single task gait performance: speed, stride length and cadence; as measured<br /><br>by the GAITRite system.<br /><br>• Single task cognitive performance (during sitting); amount of errors is<br /><br>scored during a single cognitive task which is similar to the cognitive task<br /><br>that is used in the dual task test session.</p><br>