Chronic Alcohol and Brain Stress Circuit Response
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Yale University
- Enrollment
- 120
- Locations
- 1
- Primary Endpoint
- Assess differences in reactivity to cue imagery
Study Overview
Brief Summary
Alcoholism is among the top three causes of preventable death and disease in the US (Mokdad et al., 2004; Room et al., 2005). Stress plays an important role in the development of alcoholism and in high vulnerability to alcohol relapse. This study will provide a greater understanding of the mechanism by which stress and alcohol consumption interacts to influence development of compulsive alcohol seeking and vulnerability to stress-induced drinking, and the results will have significant implications for the development of new prevention and treatment interventions for alcoholism.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 21 Years to 50 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •ages 21-50
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Assess differences in reactivity to cue imagery
Time Frame: 2 years from start of study
Physiological measures will be collected (heart rate, blood levels), self-reports of emotional states completed \& alcohol taste task performed
Secondary Outcomes
No secondary outcomes reported
Investigators
Rajita Sinha
Professor
Yale University