The influence of Vitamin B12 deficiency on the expression of Leber Hereditary Optic Neuropathy (LHON)

Completed

• Conditions: genetic disease of the optic nerve; 10047518; Leber Hereditary Optic

• Registration Number: NL-OMON36113
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 72

Inclusion Criteria

LHON patients:
-clinical characteristics of LHON
-proven LHON mutation
- recent loss of vision (not longer then half a year);Control patients:
- same gender as LHON patient for which will be matched
- same age (+/- 3 years) as LHON patient for which will be matched (but not younger then 18 years)

Exclusion Criteria

LHON patient
- younger then 18 years;Control patients
-known optic neuropathy
-actual treatment by medical specialist (except ophthalmologist)
- known bowel disease, for which patient receives treatment
- actual neurological disease, for which patient is under treatment
- known renal dysfunction
- known diabetes mellitus
- known thyroid disease
- known anemia
- veganistic diet
- excess alcohol intake (> 4 units a day)
-pregnancy
- medication: gastric acid secretion inhibitors, colchicine
- smoking

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Prevalence of a vitamin B12 deficiency in the LHON and control population.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Cause of vitamin B12 deficiency in the LHON patients</p><br>