The incidence,risk factors and association of decreased blood platelets with outcome in critically ill patients with life-threatening infectio
Not Applicable
- Conditions
- Health Condition 1: B999- Unspecified infectious disease
- Registration Number
- CTRI/2020/03/024121
- Lead Sponsor
- one
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
consecutive sepsis patients admitted to ICU, of 18-60 year age group and staying in ICU for at least 10 days
Exclusion Criteria
patients with pre-existing history of liver cirrhosis, splenomegaly, aplastic anemia, idiopathic thrombocytopenic purpura, thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, heparin-induced thrombocytopenia, pregnancy, HIV infection, systemic lupus erythematosus, vasculitis, prosthetic cardiac valve replacement, malignancy, chemotherapy in last 30 days, and any radiation therapy in last 6 months.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the 30-day mortality among sepsis patients with thrombocytopenia verses those without thrombocytopenia at ICU admissionTimepoint: ICU admission(Day 1) to 30 days
- Secondary Outcome Measures
Name Time Method Hospital length of stayTimepoint: Duration of hospital stay;maximal dose and duration of vasopressor use, need of renal replacement therapy, lowest Pao2/FiO2 ratio, major bleeding episodes and total blood products used, ICU length of stay, mechanical ventilation days, number of patients requiring mechanical ventilationTimepoint: Duration of ICU stay;To analyse the risk factors for onset of thrombocytopenia in sepsis patients on ICU admissionTimepoint: ICU admission( Day 1);To compare the mortality rate among sepsis patients developing thrombocytopenia at Day 1, Day4, and Day10, after ICU admissionTimepoint: ICU admission( Day 1) with Day 4 and Day 10;To determine the incidence of thrombocytopenia in sepsis patients during ICU stayTimepoint: ICU admission( Day 1) to Day 10