Interest of Thromboelastography (ROTEM) as a Biomarker of Revascularisation in Stroke
- Conditions
- Stroke
- Interventions
- Biological: Thromboelastography
- Registration Number
- NCT02902393
- Lead Sponsor
- University Hospital, Caen
- Brief Summary
Revascularisation using recombinant tPA is the reference treatment of stroke. However, the efficacy of fibrinolysis is about 50%. Several factors, including the size of thrombus, have been associated with revascularisation efficacy.
The aim of this prospective study is to evaluate ex vivo the effect of tPA in patients with stroke with thromboelastography and to correlate results with the clinical outcome of patients. Results may predict revascularisation in patients with stroke.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 64
Inclusion Criteria
- Patient (> 18 years) with a neurological deficit compatible with a neurovascular pathology eligible for fibrinolysis rtPA and having a proximal occlusion of the middle cerebral artery (segment M1 / M2) or basilar trunk objectified brain imaging (MRI angiography or angio CT).
Exclusion Criteria
- Any patient with major comorbidity, a pathology of hemostasis or anticoagulant treatment (vitamin K antagonist (VKA), direct oral anticoagulant).
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Success of revascularisation Thromboelastography -
- Primary Outcome Measures
Name Time Method Evaluation of revascularisation 24 hours after tPA injection using CT scan or MRI 24 hours
- Secondary Outcome Measures
Name Time Method Clinical evaluation using NIHSS scale 24 hours
Trial Locations
- Locations (1)
University Hospital
🇫🇷Caen, Calvados, France