Interest of Thromboelastography (ROTEM) as a Biomarker of Revascularisation in Stroke

University Hospital, Caen1 site in 1 country64 target enrollmentJuly 2016

ConditionsStroke

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Stroke
Sponsor: University Hospital, Caen
Enrollment: 64
Locations: 1
Primary Endpoint: Evaluation of revascularisation 24 hours after tPA injection using CT scan or MRI
Last Updated: 9 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Revascularisation using recombinant tPA is the reference treatment of stroke. However, the efficacy of fibrinolysis is about 50%. Several factors, including the size of thrombus, have been associated with revascularisation efficacy.

The aim of this prospective study is to evaluate ex vivo the effect of tPA in patients with stroke with thromboelastography and to correlate results with the clinical outcome of patients. Results may predict revascularisation in patients with stroke.

Registry

clinicaltrials.gov

Start Date

July 2016

End Date

September 2018

Last Updated

9 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

University Hospital, Caen

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Patient (\> 18 years) with a neurological deficit compatible with a neurovascular pathology eligible for fibrinolysis rtPA and having a proximal occlusion of the middle cerebral artery (segment M1 / M2) or basilar trunk objectified brain imaging (MRI angiography or angio CT).