NCT00337740终止3 期
Randomized Study Comparing Ligation With Propranolol for Primary Prophylaxis of Variceal Bleeding in Candidates for Liver Transplantation
University of Padova2 个研究点 分布在 1 个国家目标入组 120 人开始时间: 2006年6月16日最近更新:
适应症
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 终止
- 发起方
- 入组人数
- 120
- 试验地点
- 2
- 主要终点
- variceal bleeding
研究概览
简要总结
Whether beta-blockers or banding is the best therapy for primary prophylaxis of variceal bleeding is subject to debate. A randomized comparison between the two treatments was performed in candidates for liver transplantation. Patients with Child B and C cirrhosis with high risk varices and no previous variceal bleeding are randomized to propranolol or variceal bleeding. Primary end point is variceal bleeding
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •liver cirrhosis
- •child pugh>=B7
- •studied for transplantation
- •age between 18 an 65 ys
- •no previous bleeding from varices
- •signed informed consent
排除标准
- •esophageal varices less than F2 blue
- •gastric varices
- •previous variceal surgical or radiological or endoscopical treatment
- •hepatocarcinoma
- •portal vein thrombosis
- •severe heart, respiratory or renal failure
- •contraindications to betablockers
- •treatment with nitrates, calcium antagonist or anti-arhythmic drugs that can not be suspended
- •Pregnancy
- •neoplasias
- •non cooperation
结局指标
主要结局
variceal bleeding
次要结局
未报告次要终点
研究者
研究点 (2)
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