Effect of Nano-emodin on palatal wound healing
- Conditions
- Evaluation of palatal wound healing after free gingival graft surgery due to lack of attached gingiva.
- Registration Number
- IRCT20221212056791N1
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 51
Patients age = 18 years.
systemically healthy.
The graft dimensions were taken with a maximum width of ten millimeters and a length of fifteen to twenty-five millimeters.
Patients should sign the informed consent form to participate in the study after receiving sufficient information about the risks, advantages and disadvantages.
Active gag reflux.
Smoking and alcohol consumption, periodontal diseases, traumatic occlusion
systemic diseases considered either as the contra-indications of periodontal surgeries or in contradiction with wound healing process such as diabetes and history of treatment with high dose steroids
taking anti-coagulation medications, radiotherapy or other types of therapies suppressing the immunity system, pregnancy, breast-feeding, digestive disorders.
a history of taking medications distorting the wound healing process or inducing gingival enlargement.
the patients missing the follow-up sessions after the surgery.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The clinical effect of photodynamic therapy using Nano-Emodin on the palatal wound healing after free gingival graft surgery. Timepoint: Comparison of the average area of the remaining wound in the palate at intervals of 7, 14, 21 and 28 days after surgery. Comparison of the amount of bleeding after surgery in the first 7 days. Comparison of the degree of color matching and epithelialization in the time interval 7, 14, 21, 28. Comparison of the average index of pain and discomfort in the first 10 days after surgery. Method of measurement: The average area of the remaining wound in the area by image j program. Comparison of the amount of bleeding through a questionnaire. Comparison of color matching with Adobe Photoshop software. Examining the amount of epithelialization through 3% hydrogen peroxide. Index of pain and discomfort using Visual Analogue Scale.
- Secondary Outcome Measures
Name Time Method